The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Sarah K.A. Savoy; Jeanette E. Boudreau

doi:10.3390/v11100959

The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Sarah K.A. Savoy, Jeanette E. Boudreau

Medicine

Résultat de recherche: Review article › examen par les pairs

24 Citations (Scopus)

Résumé

Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA genes segregate independently, thus creating an array of reactive potentials within and between the NK cell repertoires of individuals. In this review, we discuss the interplay between NK cell education and adaptation with virus infection, with a special focus on three viruses for which the NK cell response is often studied: human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the complex co-evolution of viruses and NK cells, and their impact on viral control.

Langue d'origine	English
Numéro d'article	959
Journal	Viruses
Volume	11
Numéro de publication	10
DOI	https://doi.org/10.3390/v11100959
Statut de publication	Published - oct. 17 2019

Note bibliographique

Funding Information:
Funding: The work is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC funding reference number RGPIN-2017-06489) to J.E.B., an NSERC Undergraduate Student Research Award to S.K.A.S. and the Banting Research Foundation Discovery award to J.E.B. We gratefully acknowledge Designs that Cell for assistance with our artwork.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Infectious Diseases
Virology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.3390/v11100959

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The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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