Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial

  • Daneman, Nick N. (PI)
  • Fowler, Robert Allston R.A. (CoPI)
  • Bagshaw, Sean M S. (CoPI)
  • Coburn, Bryan Alexander B.A. (CoPI)
  • Cook, Deborah Joanne D.J. (CoPI)
  • Dodek, Peter Murray P.M. (CoPI)
  • Hall, Richard I. (CoPI)
  • Kumar, Anand (CoPI)
  • Lamontagne, Francois (CoPI)
  • Lauzier, François F. (CoPI)
  • Marshall, John Christopher (CoPI)
  • Martin, Claudio Marcelo C.M. (CoPI)
  • Mcintyre, Lauralyn Ann L.A. (CoPI)
  • Muscedere, John (CoPI)
  • Reynolds, Steven Campbell S.C. (CoPI)
  • Stelfox, Henry Thomas H. (CoPI)

Medicine

Project: Research project

Project Details

Description

Bloodstream infections are a common and serious problem, affecting 15% of critically ill patients, increasing length of hospital stay by 2-3 weeks, adding $25,000-40,000 in excess hospital costs, and tripling the risk of death. At the same time, antibiotic overuse is also a common and serious problem, in that 30-50% of antibiotic use is unnecessary or inappropriate, and results in avoidable drug side effects such as kidney failure, Clostridium difficile infection, increased costs, and spiraling antibiotic resistance rates. The greatest contributor to antibiotic overuse is excessive durations of treatment. Shorter duration antibiotic treatment (

StatusFinished
Effective start/end date7/1/15 → 6/30/16

Funding

  • Institute of Population and Public Health: US$864,552.00

ASJC Scopus Subject Areas

  • Infectious Diseases
  • Health Informatics
  • Public Health, Environmental and Occupational Health

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