Control of movement: Brain stem control of locomotion

It has been known for about one century that the spinal cord contains the nerve cells and networks necessary to produce the basic rhythm and pattern of walking. These networks are often called "central pattern generators" or CPGs. Over the last few decades, several laboratories have investigated the pathways that the brain uses to control these spinal CPGs. However, there is a paucity of details regarding these pathways. This project will use new mouse transgenic technology combined with advanced imaging techniques to study the neurons and pathways involved in activating spinal CPGs. The neurons will be identified, and their properties will be studied. The understanding of these pathways is essential to the development of strategies aimed at regenerating motor control pathways following spinal cord injury.