How does frailty influence dementia expression in Alzheimer's disease?

By 2031, 1.4 million Canadians are projected to suffer from cognitive impairment, many due to Alzheimer's Disease (AD). Drug therapies have not yet been promising in the prevention of Alzheimer's Disease and the mechanisms of it's development remain unclear. Age remains the number one risk factor for AD and many older adults are physically frail, meaning they have many interacting health problems. I plan to investigate how frailty may influence the development and progression of neurodegenerative disease, such as Alzheimer's in order to find effective strategies for prevention and treatment of this devastating disease.