Microvascular Pathology as a Therapeutic Target for Epilepsy

Approximately one third of individuals with epilepsy will continue to experience seizures despite taking appropriate medications. In this project, we aim to: (1) better understand the underpinnings of epileptic seizures; and (2) test a new treatment for epilepsy. In previous animal and human studies, we have shown that leakage of the brain's small blood vessels (micro-vessels) plays a critical role in the development of epilepsy. We have also identified promising drugs that can potentially treat these micro-vessels. Here, we will test the efficacy of these drugs in animals with epilepsy induced in laboratory settings. In parallel, we will study these micro-vessels in patients with epilepsy. Specifically, we will use a magnetic resonance imaging (MRI) method we developed, to investigate the link between leaky micro-vessels and the number and severity of seizures experienced by patients. The findings of this project stand to advance the understanding of epilepsy and pave the way towards a new treatment. Moreover, the study will provide proof-of-concept evidence for the utility of the developed diagnostic tool in the evaluation of patients with epilepsy.