Understanding the neural bases for social deficits in Alzheimer's Disease

Approximately one quarter of people with Alzheimer's disease experience behavioral symptoms including social withdrawal and/or aggression. These challenging behaviors can significantly contribute to family and caregiver burden. Aggressive behaviors can compromise the safety of affected individuals and their caregivers and contribute to repeated hospitalizations. While social withdrawal and aggression are well documented in people living with Alzheimer's disease, less is known about the specific underlying brain changes that may contribute to these symptoms.