10-gingerol inhibits ovarian cancer cell growth by inducing G2 arrest

Andrea Rasmussen, Kaylee Murphy, David W. Hoskin

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol. Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer.

Original languageEnglish
Pages (from-to)685-689
Number of pages5
JournalAdvanced Pharmaceutical Bulletin
Volume9
Issue number4
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by discretionary funds from the Canadian Cancer Society (CSS)/Canadian Breast Cancer Foundation (CBCF) and the Queen Elizabeth II Foundation, associated with the CSS/CFCF Endowed Chair in Breast Cancer Research.

Publisher Copyright:
© 2019 The Author (s).

ASJC Scopus Subject Areas

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics(all)

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