5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord

Marva Sweeney; Thomas White; Jana Sawynok

doi:10.1016/0006-8993(88)90562-8

5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord

Marva Sweeney, Thomas White, Jana Sawynok

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

5-Hydroxytryptamine (serotonin, 5-HT) increased the release of endogenous adenosine from dorsal, but not ventral, spinal cord synaptosomes. This release was reduced by (i) the 5-HT receptor antagonist methysergide, (ii) removal of Ca²⁺ from the medium, (iii) inhibition of ecto-5′-nucleotidase and (iv) capsaicin pretreatment. These data suggest that activation of 5-HT receptors on primary afferent terminals releases a nucleotide which is converted extracellularly to adenosine. This adenosine may contribute to the spinal antinociceptive effect of 5-HT.

Original language	English
Pages (from-to)	346-349
Number of pages	4
Journal	Brain Research
Volume	462
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90562-8
Publication status	Published - Oct 18 1988

Bibliographical note

Funding Information:
This work was supported by the Medical Research Council of Canada in grants to T.W. and J.S.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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abstract = "5-Hydroxytryptamine (serotonin, 5-HT) increased the release of endogenous adenosine from dorsal, but not ventral, spinal cord synaptosomes. This release was reduced by (i) the 5-HT receptor antagonist methysergide, (ii) removal of Ca2+ from the medium, (iii) inhibition of ecto-5′-nucleotidase and (iv) capsaicin pretreatment. These data suggest that activation of 5-HT receptors on primary afferent terminals releases a nucleotide which is converted extracellularly to adenosine. This adenosine may contribute to the spinal antinociceptive effect of 5-HT.",

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AB - 5-Hydroxytryptamine (serotonin, 5-HT) increased the release of endogenous adenosine from dorsal, but not ventral, spinal cord synaptosomes. This release was reduced by (i) the 5-HT receptor antagonist methysergide, (ii) removal of Ca2+ from the medium, (iii) inhibition of ecto-5′-nucleotidase and (iv) capsaicin pretreatment. These data suggest that activation of 5-HT receptors on primary afferent terminals releases a nucleotide which is converted extracellularly to adenosine. This adenosine may contribute to the spinal antinociceptive effect of 5-HT.

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5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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