Abstract
Guanoxan and guanethidine were studied in 52 patients with essential hypertension using a double-blind crossover technique. No difference was seen in the hypotensive effects of the two drugs. Blood pressure in the standing position (systolic /diastolic) was decreased by 30 25 mm. Hg and in the recumbent position, by 20 15 mm. Hg; postexercise blood pressure was decreased by 45 40 mm. Hg. Fatigue was a more common complaint after administration of guanethidine, but otherwise guanoxan and guanethidine were similar in efficacy and in adverse effects. Twenty-four hour urinary excretion of norepinephrine, but not epinephrine, was decreased during therapy with both drugs.
Original language | English |
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Pages (from-to) | 38-47 |
Number of pages | 10 |
Journal | Clinical Pharmacology and Therapeutics |
Volume | 8 |
Issue number | 1 PART 1 |
DOIs | |
Publication status | Published - 1967 |
Externally published | Yes |
ASJC Scopus Subject Areas
- Pharmacology
- Pharmacology (medical)