A comparison of (±)epibatidine with NMDA in releasing [3H]noradrenaline and adenosine from slices of rat hippocampus and parietal cortex

Thomas D. White; Kazue Semba

doi:10.1016/S0304-3940(97)00734-9

A comparison of (±)epibatidine with NMDA in releasing [³H]noradrenaline and adenosine from slices of rat hippocampus and parietal cortex

Thomas D. White, Kazue Semba

Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We compared (±)epibatidine with N-methyl-D-aspartate (NMDA) in releasing adenosine and [³H]noradrenaline from slices of rat hippocampus and parietal cortex. (±)Epibatidine (0.1 μM) released [³H]noradrenaline but not adenosine from hippocampal slices incubated either with or without extracellular Mg²⁺. In contrast, NMDA (300 μM) released much more [³H]noradrenaline and also adenosine from hippocampal slices incubated in medium lacking Mg²⁺. (±)Epibatidine released neither adenosine nor [³H]noradrenaline from slices of rat parietal cortex, in contrast to NMDA which released both substances. These findings suggest that those behavioral responses to (±)epibatidine that are mediated by noradrenaline may involve the hippocampus but not the parietal cortex. Moreover, it seems unlikely that any of the behavioral effects of (±)epibatidine are mediated by adenosine release in either the parietal cortex or the hippocampus.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	Neuroscience Letters
Volume	235
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(97)00734-9
Publication status	Published - Oct 17 1997

Bibliographical note

Funding Information:
We thank Sharon Temple and Joan Burns for their excellent technical work. Research supported by grants from the M.R.C. of Canada to T.D.W and K.S.

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1016/S0304-3940(97)00734-9

Cite this

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title = "A comparison of (±)epibatidine with NMDA in releasing [3H]noradrenaline and adenosine from slices of rat hippocampus and parietal cortex",

abstract = "We compared (±)epibatidine with N-methyl-D-aspartate (NMDA) in releasing adenosine and [3H]noradrenaline from slices of rat hippocampus and parietal cortex. (±)Epibatidine (0.1 μM) released [3H]noradrenaline but not adenosine from hippocampal slices incubated either with or without extracellular Mg2+. In contrast, NMDA (300 μM) released much more [3H]noradrenaline and also adenosine from hippocampal slices incubated in medium lacking Mg2+. (±)Epibatidine released neither adenosine nor [3H]noradrenaline from slices of rat parietal cortex, in contrast to NMDA which released both substances. These findings suggest that those behavioral responses to (±)epibatidine that are mediated by noradrenaline may involve the hippocampus but not the parietal cortex. Moreover, it seems unlikely that any of the behavioral effects of (±)epibatidine are mediated by adenosine release in either the parietal cortex or the hippocampus.",

author = "White, {Thomas D.} and Kazue Semba",

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AU - Semba, Kazue

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N2 - We compared (±)epibatidine with N-methyl-D-aspartate (NMDA) in releasing adenosine and [3H]noradrenaline from slices of rat hippocampus and parietal cortex. (±)Epibatidine (0.1 μM) released [3H]noradrenaline but not adenosine from hippocampal slices incubated either with or without extracellular Mg2+. In contrast, NMDA (300 μM) released much more [3H]noradrenaline and also adenosine from hippocampal slices incubated in medium lacking Mg2+. (±)Epibatidine released neither adenosine nor [3H]noradrenaline from slices of rat parietal cortex, in contrast to NMDA which released both substances. These findings suggest that those behavioral responses to (±)epibatidine that are mediated by noradrenaline may involve the hippocampus but not the parietal cortex. Moreover, it seems unlikely that any of the behavioral effects of (±)epibatidine are mediated by adenosine release in either the parietal cortex or the hippocampus.

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