A modification of the urine osmolal gap: An improved method for estimating urine ammonium

Roland F. Dyck, Sanjay Asthana, J. Kalra, Michael L. West, K. Lorne Massey

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A modification of the urine osmolal gap was evaluated as an estimate of urine [NH4]. We proposed that: (Equation Present) Spot urine samples were collected from normal volunteers and from individuals with ketonuria; the modified urine osmolal gap as well as two other previously described estimates of urine [NH+4] were compared with measured urine [NH+4]. There was a significant positive linear correlation between the urine [NH+4] and the modified urine osmolal gap in normal volunteers (r = 0.81; p < 0.01) and in individuals with ketonuria (r = 0.93; p < 0.001). The originally described urine osmolal gap greatly overestimated the urine [NH+4] but also showed a significant correlation. The urine anion gap was not a valid estimate of urine [NH+4] within the range of values measured in our subjects. The modified urine osmolal gap is an improvement over previously described estimates of urine [NH+4] and can be used as a single calculation in place of the other two.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalAmerican Journal of Nephrology
Volume10
Issue number5
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus Subject Areas

  • Nephrology

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article

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Dyck, R. F., Asthana, S., Kalra, J., West, M. L., & Massey, K. L. (1990). A modification of the urine osmolal gap: An improved method for estimating urine ammonium. American Journal of Nephrology, 10(5), 359-362. https://doi.org/10.1159/000168150