A two-stage cold isostatic pressing and gelling approach for fabricating a therapeutically loaded amorphous calcium polyphosphate local delivery system

Patricia Comeau, Mark Filiaggi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Local delivery systems have taken on a greater clinical focus for osteomyelitis therapy owing to their ability to overcome many disadvantages of systemic delivery. This study reports for the first time the capacity to fabricate strontium- and vancomycin-doped calcium polyphosphate beads using a two-stage cold isostatic pressing and gelling approach. The fabricated beads were of uniform shape and diameter, and upon gelling exhibited reduced porosity. Of greatest significance in the subsequent in vitro study was the improvement of bead long-term structural stability upon vancomycin incorporation; a characteristic that further encourages the extended release of therapeutically relevant levels of antibiotic. Overall, this study provides support for the inclusion of a cold isostatic pressing step in the fabrication of a therapeutically loaded calcium polyphosphate bead-based local delivery system intended for osteomyelitis treatment.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalJournal of Biomaterials Applications
Volume32
Issue number1
DOIs
Publication statusPublished - Jul 1 2017

Bibliographical note

Publisher Copyright:
© The Author(s) 2017.

ASJC Scopus Subject Areas

  • Biomaterials
  • Biomedical Engineering

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