Action of coenzyme A on adenine derivative receptors in isolated tissues

Khem Jhamandas; Kanji Nakatsu; John W. Downie; Verna Bartlett; Janet Elliott

doi:10.1016/0014-2999(80)90091-6

Action of coenzyme A on adenine derivative receptors in isolated tissues

Khem Jhamandas, Kanji Nakatsu, John W. Downie, Verna Bartlett, Janet Elliott

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The action of Coenzyme A (CoA) was investigated on the mechanical activity of four isolated tissues known to possess adenine derivative (AD) receptors that are sensitive, or resistant to blockade by theophylline. CoA produced a dose-related inhibition of the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig ileum, and of the spontaneously contracting rabbit ileum. This effect was competitively antagonized by theophylline in both tissues. CoA caused a dose-related relaxation of the rat ileum. Low doses of CoA were not antagonized by theophylline but higher doses were antagonized by this drug. The rabbit detrusor, which was contracted by ATP and ADP, was not affected by CoA. Differences in the action of CoA at AD receptors in these four tissues, and in its antagonism by theophylline reflect a heterogeneity of these receptors. It is suggested that the simple sub-division of adenine derivative receptors into two types may be inappropriate.

Original language	English
Pages (from-to)	247-252
Number of pages	6
Journal	European Journal of Pharmacology
Volume	62
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(80)90091-6
Publication status	Published - Apr 4 1980
Externally published	Yes

Bibliographical note

Funding Information:
This work was supportedb y individuarl esearch grantst o Khem JhamandasK,a nji Nakatsua ndJohn W. Downie from the Medical ResearchC ouncil of Canada. Dr. Downie is a Scholar of the Medical ResearchC ouncil.

ASJC Scopus Subject Areas

Pharmacology

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title = "Action of coenzyme A on adenine derivative receptors in isolated tissues",

abstract = "The action of Coenzyme A (CoA) was investigated on the mechanical activity of four isolated tissues known to possess adenine derivative (AD) receptors that are sensitive, or resistant to blockade by theophylline. CoA produced a dose-related inhibition of the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig ileum, and of the spontaneously contracting rabbit ileum. This effect was competitively antagonized by theophylline in both tissues. CoA caused a dose-related relaxation of the rat ileum. Low doses of CoA were not antagonized by theophylline but higher doses were antagonized by this drug. The rabbit detrusor, which was contracted by ATP and ADP, was not affected by CoA. Differences in the action of CoA at AD receptors in these four tissues, and in its antagonism by theophylline reflect a heterogeneity of these receptors. It is suggested that the simple sub-division of adenine derivative receptors into two types may be inappropriate.",

author = "Khem Jhamandas and Kanji Nakatsu and Downie, {John W.} and Verna Bartlett and Janet Elliott",

note = "Funding Information: This work was supportedb y individuarl esearch grantst o Khem JhamandasK,a nji Nakatsua ndJohn W. Downie from the Medical ResearchC ouncil of Canada. Dr. Downie is a Scholar of the Medical ResearchC ouncil.",

year = "1980",

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doi = "10.1016/0014-2999(80)90091-6",

language = "English",

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AU - Jhamandas, Khem

AU - Nakatsu, Kanji

AU - Downie, John W.

AU - Bartlett, Verna

AU - Elliott, Janet

N1 - Funding Information: This work was supportedb y individuarl esearch grantst o Khem JhamandasK,a nji Nakatsua ndJohn W. Downie from the Medical ResearchC ouncil of Canada. Dr. Downie is a Scholar of the Medical ResearchC ouncil.

PY - 1980/4/4

Y1 - 1980/4/4

N2 - The action of Coenzyme A (CoA) was investigated on the mechanical activity of four isolated tissues known to possess adenine derivative (AD) receptors that are sensitive, or resistant to blockade by theophylline. CoA produced a dose-related inhibition of the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig ileum, and of the spontaneously contracting rabbit ileum. This effect was competitively antagonized by theophylline in both tissues. CoA caused a dose-related relaxation of the rat ileum. Low doses of CoA were not antagonized by theophylline but higher doses were antagonized by this drug. The rabbit detrusor, which was contracted by ATP and ADP, was not affected by CoA. Differences in the action of CoA at AD receptors in these four tissues, and in its antagonism by theophylline reflect a heterogeneity of these receptors. It is suggested that the simple sub-division of adenine derivative receptors into two types may be inappropriate.

AB - The action of Coenzyme A (CoA) was investigated on the mechanical activity of four isolated tissues known to possess adenine derivative (AD) receptors that are sensitive, or resistant to blockade by theophylline. CoA produced a dose-related inhibition of the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig ileum, and of the spontaneously contracting rabbit ileum. This effect was competitively antagonized by theophylline in both tissues. CoA caused a dose-related relaxation of the rat ileum. Low doses of CoA were not antagonized by theophylline but higher doses were antagonized by this drug. The rabbit detrusor, which was contracted by ATP and ADP, was not affected by CoA. Differences in the action of CoA at AD receptors in these four tissues, and in its antagonism by theophylline reflect a heterogeneity of these receptors. It is suggested that the simple sub-division of adenine derivative receptors into two types may be inappropriate.

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 4

ER -

Action of coenzyme A on adenine derivative receptors in isolated tissues

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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