Activation of metabotropic glutamate receptors increases extracellular adenosine in vivo

Hilary J. Bennett, Thomas D. White, Kazue Semba

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

In order to identify the mechanisms that would lead to increased levels of the inhibitory neuromodulator adenosine in the brain, we tested metabotropic glutamate receptor agonists for their ability to increase extracellular adenosine in the cortex of unanesthetized rat using in vivo microdialysis. The group I/II metabotropic glutamate receptor agonist trans-(±)-1-amino-(1S,3R)-cyclopenyanedicarboxylic acid (1 mM) increased extracellular adenosine as did the specific group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG; 1 mM). The evoked increase of adenosine by 1 mM DHPG was reduced by the group I antagonist (RS)-1-aminoindan-1,5,-dicarboxylic acid. Activation of group II or III metabotropic receptors did not affect extracellular adenosine. These results suggest that activation of group I metabotropic receptors contributes to elevated extracellular adenosine levels in vivo. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)3489-3492
Number of pages4
JournalNeuroReport
Volume11
Issue number16
DOIs
Publication statusPublished - Nov 9 2000

ASJC Scopus Subject Areas

  • General Neuroscience

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