Adoptive transfer of immunity to Trichinella spiralis in mice: Generation of effective cells by different life cycle stages

R. K. Grencis, T. D.G. Lee, D. Wakelin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Adoptive transfer of immunity with day 8 mesenteric lymph node cells (MLNC) taken from NIH mice after a chemically abbreviated infection of 3 days duration was as effective as transfer with cells taken from mice which had received an uninterrupted infection. Using a surgical transplantation technique it was demonstrated that adult T. spiralis were not capable of stimulating cells effective upon adoptive transfer. The potent immunogenicity of the early stages of infection was emphasized by data showing that very low numbers of muscle larvae were efficient in stimulating effective mediator cells. Neither the time at which MLNC were taken for transfer after transplantation of adult worms nor the age of adult worms transplanted affected the failure of this life cycle stage to stimulate cells capable of mediating worm expulsion. It is proposed that expulsion of T. spiralis from the gut may be achieved by more than one effector mechanism, and that early and late intestinal stages stimulate these mechanisms differentially.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalInternational Journal for Parasitology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1985
Externally publishedYes

Bibliographical note

Funding Information:
The concept of mucosal immunity to parasites involving multiple mechanisms is not new and is supported by substantial evidence (see Bcfus & Bicncnstock, 1982). Indeed in the T. spiral&mouse system a recent synthesis (Wassom. Wakclin, Brooks, Krco & David, 1983) proposes that anti-fecundity, anti-adult, and rapid expulsion responses arc under independent genetic control. This rcin-forces the proporal that expulsion of the worm from the intestine results from multiple distinct immunological mechanisms. and further emphasizes the complexity of host responses generated by parasitic organisms living within the gastrointestinal tract. Ac~nowledRemenfs-This work was tupportcd by research Irainmg award J77:689b and projccr granr 80 tK)58 from Ihc Medical Rcscarch Council. RF~EREtiCES H~rr.s A. I). & HIES~SST~K’K J 1982. Facrors involved in symbiosis and host resistance ar the mucosa-parasite interface. f’rogress tn A//ergy 31: 76 177.

ASJC Scopus Subject Areas

  • Parasitology
  • Infectious Diseases

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