TY - JOUR
T1 - Advances in degradable embolic microspheres
T2 - A state of the art review
AU - Doucet, Jensen
AU - Kiri, Lauren
AU - O'Connell, Kathleen
AU - Kehoe, Sharon
AU - Lewandowski, Robert J.
AU - Liu, David M.
AU - Abraham, Robert J.
AU - Boyd, Daniel
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/1/26
Y1 - 2018/1/26
N2 - Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies.
AB - Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies.
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U2 - 10.3390/jfb9010014
DO - 10.3390/jfb9010014
M3 - Review article
AN - SCOPUS:85050974404
SN - 2079-4983
VL - 9
JO - Journal of Functional Biomaterials
JF - Journal of Functional Biomaterials
IS - 1
M1 - 14
ER -