Age-related deficit accumulation and the diseases of ageing

Kenneth Rockwood; Susan E. Howlett

doi:10.1016/j.mad.2019.04.005

Age-related deficit accumulation and the diseases of ageing

Kenneth Rockwood, Susan E. Howlett

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. The many effects of age-related changes can be demonstrated epidemiologically, and in preclinical models, using a frailty index to distinguish between the contributions of traditional and non-traditional risk factors. Quantifying the contribution of age-related deficit accumulation in clinical and preclinical samples offers a powerful new tool for understanding mechanisms of age-related disease. It appears that a range of common late-life illnesses might be targeted by drugs aimed at ageing processes.

Original language	English
Pages (from-to)	107-116
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	180
DOIs	https://doi.org/10.1016/j.mad.2019.04.005
Publication status	Published - Jun 2019

Bibliographical note

Funding Information:
Canadian Institutes of Health Research (CIHR)for KR: PJT 156114; for SEH CIHR PJT 155961 and 162462. Both are also supported by the Fountain Family Innovation Fund of the Queen Elizabeth II Health Sciences Foundation.

Funding Information:
Canadian Institutes of Health Research (CIHR) for KR: PJT 156114 ; for SEH CIHR PJT 155961 and 162462 . Both are also supported by the Fountain Family Innovation Fund of the Queen Elizabeth II Health Sciences Foundation .

Publisher Copyright:
© 2019 The Authors

ASJC Scopus Subject Areas

Ageing
Developmental Biology

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10.1016/j.mad.2019.04.005

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abstract = "With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. The many effects of age-related changes can be demonstrated epidemiologically, and in preclinical models, using a frailty index to distinguish between the contributions of traditional and non-traditional risk factors. Quantifying the contribution of age-related deficit accumulation in clinical and preclinical samples offers a powerful new tool for understanding mechanisms of age-related disease. It appears that a range of common late-life illnesses might be targeted by drugs aimed at ageing processes.",

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AB - With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. The many effects of age-related changes can be demonstrated epidemiologically, and in preclinical models, using a frailty index to distinguish between the contributions of traditional and non-traditional risk factors. Quantifying the contribution of age-related deficit accumulation in clinical and preclinical samples offers a powerful new tool for understanding mechanisms of age-related disease. It appears that a range of common late-life illnesses might be targeted by drugs aimed at ageing processes.

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Age-related deficit accumulation and the diseases of ageing

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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