Abstract
Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden cardiac death (SCD). The electrophysiological changes involved have been extensively studied, yet the mechanisms of ventricular arrhythmias during acute ischemia remain unclear. What is known is that during acute ischemia both focal (ectopic excitation) and nonfocal (reentry) arrhythmias occur, due to an interaction of altered electrical, mechanical, and biochemical properties of the myocardium. There is particular interest in the role that alterations in intracellular calcium handling, which cause changes in intracellular calcium concentration and to the calcium transient, play in ischemia-induced arrhythmias. In this review, we briefly summarize the known contributors to ventricular arrhythmias during acute ischemia, followed by an in-depth examination of the potential contribution of altered intracellular calcium handling, which may include novel targets for antiarrhythmic therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 61-69 |
| Number of pages | 9 |
| Journal | Clinical Medicine Insights: Cardiology |
| Volume | 10s1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
Bibliographical note
Funding Information:fUNDINg: this work was supported by the Canadian institutes of health research (MoP-142424) and the nova scotia health research Foundation (Med-est-2014-9582). taQ is a national new investigator of the heart and stroke Foundation of Canada. the authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.
Publisher Copyright:
© 2016, © 2016 SAGE Publications.
ASJC Scopus Subject Areas
- Cardiology and Cardiovascular Medicine