TY - JOUR
T1 - Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients
T2 - An fmri study
AU - Spaniel, Filip
AU - Tintera, Jaroslav
AU - Rydlo, Jan
AU - Ibrahim, Ibrahim
AU - Kasparek, Tomas
AU - Horacek, Jiri
AU - Zaytseva, Yuliya
AU - Matejka, Martin
AU - Fialova, Marketa
AU - Slovakova, Andrea
AU - Mikolas, Pavol
AU - Melicher, Tomas
AU - Görnerova, Natalie
AU - Höschl, Cyril
AU - Hajek, Tomas
N1 - Publisher Copyright:
© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2016/7
Y1 - 2016/7
N2 - Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooledsample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During selfagency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
AB - Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooledsample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During selfagency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
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U2 - 10.1093/schbul/sbv188
DO - 10.1093/schbul/sbv188
M3 - Article
C2 - 26685867
AN - SCOPUS:84979224991
SN - 0586-7614
VL - 42
SP - 916
EP - 925
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -
