Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium

Khem Jhamandas; Jana Sawynok; Maaja Sutak

doi:10.1016/0014-2999(78)90108-5

Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium

Khem Jhamandas, Jana Sawynok, Maaja Sutak

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The inhibitory effect of morphine on the release of acetylcholine (ACh) from the rat cerebral cortex was antagonized by theophylline, caffeine and 3-isobutyl-1-methylxanthine (IBMX). Theophylline antagonism of morphine action was dose related and this agent failed to influence a comparable action of chlorpromazine on the release of ACh. Intraventricular injection of calcium also antagonized the anti-release effect of morphine. Neither methylxanthines nor calcium modified the spontaneous release of ACh in the absence of morphine. It is suggested that methylxanthine antagonism of morphine action is selective and that is could be related to the ability of methylxanthines to mobilize bound calcium.

Original language	English
Pages (from-to)	309-312
Number of pages	4
Journal	European Journal of Pharmacology
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(78)90108-5
Publication status	Published - Jun 1 1978
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Medical Research Council of Canada. J.S. is the recipient of a research scholarship from the Addiction Research Foundation of Ontario.

ASJC Scopus Subject Areas

Pharmacology

PubMed: MeSH publication types

Journal Article

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10.1016/0014-2999(78)90108-5

Cite this

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title = "Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium",

abstract = "The inhibitory effect of morphine on the release of acetylcholine (ACh) from the rat cerebral cortex was antagonized by theophylline, caffeine and 3-isobutyl-1-methylxanthine (IBMX). Theophylline antagonism of morphine action was dose related and this agent failed to influence a comparable action of chlorpromazine on the release of ACh. Intraventricular injection of calcium also antagonized the anti-release effect of morphine. Neither methylxanthines nor calcium modified the spontaneous release of ACh in the absence of morphine. It is suggested that methylxanthine antagonism of morphine action is selective and that is could be related to the ability of methylxanthines to mobilize bound calcium.",

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AU - Jhamandas, Khem

AU - Sawynok, Jana

AU - Sutak, Maaja

N1 - Funding Information: This work was supported by the Medical Research Council of Canada. J.S. is the recipient of a research scholarship from the Addiction Research Foundation of Ontario.

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N2 - The inhibitory effect of morphine on the release of acetylcholine (ACh) from the rat cerebral cortex was antagonized by theophylline, caffeine and 3-isobutyl-1-methylxanthine (IBMX). Theophylline antagonism of morphine action was dose related and this agent failed to influence a comparable action of chlorpromazine on the release of ACh. Intraventricular injection of calcium also antagonized the anti-release effect of morphine. Neither methylxanthines nor calcium modified the spontaneous release of ACh in the absence of morphine. It is suggested that methylxanthine antagonism of morphine action is selective and that is could be related to the ability of methylxanthines to mobilize bound calcium.

AB - The inhibitory effect of morphine on the release of acetylcholine (ACh) from the rat cerebral cortex was antagonized by theophylline, caffeine and 3-isobutyl-1-methylxanthine (IBMX). Theophylline antagonism of morphine action was dose related and this agent failed to influence a comparable action of chlorpromazine on the release of ACh. Intraventricular injection of calcium also antagonized the anti-release effect of morphine. Neither methylxanthines nor calcium modified the spontaneous release of ACh in the absence of morphine. It is suggested that methylxanthine antagonism of morphine action is selective and that is could be related to the ability of methylxanthines to mobilize bound calcium.

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Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium

Abstract

Bibliographical note

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