Antidepressant drugs and heart electrical field

J. Slavíček, I. Paclt, J. Hamplová, O. Kittnar, Z. Trefný, B. M. Horáček

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Some antidepressant drugs, especially tricyclic ones - (TCA), have cardiovascular side effects. To compare the effects of antidepressant drugs, the electrocardiogram (ECG), vectorcardiogram (VCG), and body surface maps (BSM) were recorded in psychiatric patients without cardiovascular diseases treated by a) TCA amitriptyline or dosulepin (daily dose 50-200 mg, 22 patients), b) lithium (serum level 0.66 ± 0.08 meq/l, 21 patients), c) selective serotonine reuptake inhibitor citalopram (daily doses 20-60 mg, 30 patients), and in 23 control patients. In the TCA-treated patients, the heart rate was increased, QT and RR intervals shortened (p<0.01, antimuscarinic effect). This was not observed in lithium- and citalopram-treated patients. All antidepressants decreased the absolute maximum values of depolarization isointegral maps, lithium and TCA reduced the initial and citalopram the later phase of depolarization. Citalopram slightly diminished the amplitude of the R wave. The results confirm the antimuscarinic effects of TCA in therapeutic doses and specify the intraventricular effects of antidepressants.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalPhysiological Research
Volume47
Issue number4
Publication statusPublished - 1998

ASJC Scopus Subject Areas

  • Physiology

Fingerprint

Dive into the research topics of 'Antidepressant drugs and heart electrical field'. Together they form a unique fingerprint.

Cite this