Antiviral activities of silymarin and derivatives

Ching Hsuan Liu; Alagie Jassey; Hsin Ya Hsu; Liang Tzung Lin

doi:10.3390/molecules24081552

Antiviral activities of silymarin and derivatives

Ching Hsuan Liu, Alagie Jassey, Hsin Ya Hsu, Liang Tzung Lin

Medicine

Research output: Contribution to journal › Review article › peer-review

77 Citations (Scopus)

Abstract

Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

Original language	English
Article number	1552
Journal	Molecules
Volume	24
Issue number	8
DOIs	https://doi.org/10.3390/molecules24081552
Publication status	Published - Apr 19 2019

Bibliographical note

Funding Information:
This research was supported in part by funding from the Ministry of Science and Technology of Taiwan (MOST107-2320-B-038-034-MY3) and a grant from Chi-Mei Medical Center and Taipei Medical University (108CM-TMU-02). C.-H.L. is a recipient of the Canadian Network on Hepatitis C (CanHepC) PhD Fellowship.

Publisher Copyright:
© 2019 by the authors.

ASJC Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules24081552

Cite this

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abstract = "Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.",

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AB - Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

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Antiviral activities of silymarin and derivatives

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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