Antiviral amentoflavone from Selaginella sinensis

Shuang Cheng Ma; Paul Pui Hay But; Vincent Eng Choon Ooi; Yue Hua He; Spencer Hon Sun Lee; Song Fong Lee; Rui Chao Lin

doi:10.1248/bpb.24.311

Antiviral amentoflavone from Selaginella sinensis

Shuang Cheng Ma, Paul Pui Hay But, Vincent Eng Choon Ooi, Yue Hua He, Spencer Hon Sun Lee, Song Fong Lee, Rui Chao Lin

Medicine

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC₅₀ of 5.5 μg/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC. S. sinensis showed a higher content of 1.13%.

Original language	English
Pages (from-to)	311-312
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	24
Issue number	3
DOIs	https://doi.org/10.1248/bpb.24.311
Publication status	Published - 2001

ASJC Scopus Subject Areas

Pharmacology
Pharmaceutical Science

PubMed: MeSH publication types

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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AU - Lee, Song Fong

AU - Lin, Rui Chao

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AB - Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC. S. sinensis showed a higher content of 1.13%.

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Antiviral amentoflavone from Selaginella sinensis

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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