Lazarus, M., Shen, H. Y., Cherasse, Y., Qu, W. M., Huang, Z. L., Bass, C. E., Winsky-Sommerer, R., Semba, K., Fredholm, B. B., Boison, D., Hayaishi, O., Urade, Y., & Chen, J. F. (2011). Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. Journal of Neuroscience, 31(27), 10067-10075. https://doi.org/10.1523/JNEUROSCI.6730-10.2011
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. / Lazarus, Michael; Shen, Hai Ying; Cherasse, Yoan et al.
In:
Journal of Neuroscience, Vol. 31, No. 27, 06.07.2011, p. 10067-10075.
Research output: Contribution to journal › Article › peer-review
Lazarus, M, Shen, HY, Cherasse, Y, Qu, WM, Huang, ZL, Bass, CE, Winsky-Sommerer, R, Semba, K, Fredholm, BB, Boison, D, Hayaishi, O, Urade, Y & Chen, JF 2011, 'Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens', Journal of Neuroscience, vol. 31, no. 27, pp. 10067-10075. https://doi.org/10.1523/JNEUROSCI.6730-10.2011
Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE et al. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. Journal of Neuroscience. 2011 Jul 6;31(27):10067-10075. doi: 10.1523/JNEUROSCI.6730-10.2011
Lazarus, Michael ; Shen, Hai Ying ; Cherasse, Yoan et al. / Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 27. pp. 10067-10075.
@article{f0439bc4bcaa46588df11eb9c45fa533,
title = "Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens",
abstract = "Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist. It promotes wakefulness by blocking adenosineA2A receptors (A2ARs) in the brain, but the specific neurons on which caffeine acts to produce arousal have not been identified. Using selective gene deletion strategies based on the Cre/loxP technology in mice and focal RNA interference to silence the expression of A2ARs in rats by local infection with adeno-associated virus carrying short-hairpin RNA, we report that theA2ARs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness. Caffeine-induced arousal was not affected in rats when A2ARs were focally removed from the NAc core or other A2AR-positive areas of the basal ganglia. Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain.",
author = "Michael Lazarus and Shen, {Hai Ying} and Yoan Cherasse and Qu, {Wei Min} and Huang, {Zhi Li} and Bass, {Caroline E.} and Raphaelle Winsky-Sommerer and Kazue Semba and Fredholm, {Bertil B.} and Detlev Boison and Osamu Hayaishi and Yoshihiro Urade and Chen, {Jiang Fan}",
year = "2011",
month = jul,
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doi = "10.1523/JNEUROSCI.6730-10.2011",
language = "English",
volume = "31",
pages = "10067--10075",
journal = "Journal of Neuroscience",
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publisher = "Society for Neuroscience",
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T1 - Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
AU - Lazarus, Michael
AU - Shen, Hai Ying
AU - Cherasse, Yoan
AU - Qu, Wei Min
AU - Huang, Zhi Li
AU - Bass, Caroline E.
AU - Winsky-Sommerer, Raphaelle
AU - Semba, Kazue
AU - Fredholm, Bertil B.
AU - Boison, Detlev
AU - Hayaishi, Osamu
AU - Urade, Yoshihiro
AU - Chen, Jiang Fan
PY - 2011/7/6
Y1 - 2011/7/6
N2 - Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist. It promotes wakefulness by blocking adenosineA2A receptors (A2ARs) in the brain, but the specific neurons on which caffeine acts to produce arousal have not been identified. Using selective gene deletion strategies based on the Cre/loxP technology in mice and focal RNA interference to silence the expression of A2ARs in rats by local infection with adeno-associated virus carrying short-hairpin RNA, we report that theA2ARs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness. Caffeine-induced arousal was not affected in rats when A2ARs were focally removed from the NAc core or other A2AR-positive areas of the basal ganglia. Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain.
AB - Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist. It promotes wakefulness by blocking adenosineA2A receptors (A2ARs) in the brain, but the specific neurons on which caffeine acts to produce arousal have not been identified. Using selective gene deletion strategies based on the Cre/loxP technology in mice and focal RNA interference to silence the expression of A2ARs in rats by local infection with adeno-associated virus carrying short-hairpin RNA, we report that theA2ARs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness. Caffeine-induced arousal was not affected in rats when A2ARs were focally removed from the NAc core or other A2AR-positive areas of the basal ganglia. Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain.
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