TY - JOUR
T1 - Arsenic exposure and the induction of human cancers
AU - Martinez, Victor D.
AU - Vucic, Emily A.
AU - Becker-Santos, Daiana D.
AU - Gil, Lionel
AU - Lam, Wan L.
PY - 2011
Y1 - 2011
N2 - Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities to development of malignancies, such as skin and lung cancer. Despite well-known arsenic-related health effects, the molecular mechanisms involved are not fully understood; however, the arsenic biotransformation process, which includes methylation changes, is thought to play a key role. This paper explores the relationship of arsenic exposure with cancer development and summarizes current knowledge of the potential mechanisms that may contribute to the neoplastic processes observed in arsenic exposed human populations.
AB - Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities to development of malignancies, such as skin and lung cancer. Despite well-known arsenic-related health effects, the molecular mechanisms involved are not fully understood; however, the arsenic biotransformation process, which includes methylation changes, is thought to play a key role. This paper explores the relationship of arsenic exposure with cancer development and summarizes current knowledge of the potential mechanisms that may contribute to the neoplastic processes observed in arsenic exposed human populations.
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U2 - 10.1155/2011/431287
DO - 10.1155/2011/431287
M3 - Review article
C2 - 22174709
AN - SCOPUS:84855280807
SN - 1687-8191
VL - 2011
JO - Journal of Toxicology
JF - Journal of Toxicology
M1 - 431287
ER -
