Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - A Danish population-based study

Thomas M. Laursen, Betina B. Trabjerg, Ole Mors, Anders D. Børglum, David M. Hougaard, Manuel Mattheisen, Sandra M. Meier, Enda M. Byrne, Preben B. Mortensen, Trine Munk-Olsen, Esben Agerbo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background It is unknown whether an increased genetic liability to schizophrenia influences the risk of dying early. The aim of the study was to determine whether the genetic predisposition to schizophrenia is associated with the risk of dying early and experience a suicide attempt. Method Case control study, Denmark. The main measure was the mortality rate ratios (MRR) for deaths and odds ratios (OR) for multiple suicide attempts, associated with one standard deviations increase of the polygenic risk-score for schizophrenia (PRS). Results We replicated the high mortality MRR = 9.01 (95% CI: 3.56–22.80), and high risk of multiple suicide attempts OR = 33.16 (95% CI: 20.97–52.43) associated with schizophrenia compared to the general population. However, there was no effect of the PRS on mortality MRR = 1.00 (95% CI 0.71–1.40) in the case-control setup or in cases only, MRR = 1.05 (95% CI 0.73–1.51). Similar, no association between the PRS and multiple suicide attempts was found in the adjusted models, but in contrast, family history of mental disorders was associated with both outcomes. Conclusions A genetic predisposition for schizophrenia, measured by PRS, has little influence on the excess mortality or the risk of suicide attempts. In contrast there is a strong significant effect of family history of mental disorders. Our findings could reflect that the common variants detected by recent PRS only explain a small proportion of risk of schizophrenia, and that future, more powerful PRS instruments may be able to predict excess mortality within this disorder.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalSchizophrenia Research
Volume184
DOIs
Publication statusPublished - Jun 2017
Externally publishedYes

Bibliographical note

Funding Information:
The study was supported by an unrestricted grant from the Lundbeck Foundation (R155-2014-1724). The funding bodies played no role in the design of the study, preparation of the manuscript, or decision to publish.

Publisher Copyright:
© 2016

ASJC Scopus Subject Areas

  • Psychiatry and Mental health
  • Biological Psychiatry

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - A Danish population-based study'. Together they form a unique fingerprint.

Cite this