Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Gary S. Goldfield; Jeremy Walsh; Ronald J. Sigal; Glen P. Kenny; Stasia Hadjiyannakis; Michael De Lisio; Mathew Ngu; Denis Prud’homme; Angela S. Alberga; Steve Doucette; Diana B. Goldfield; Jameason D. Cameron

doi:10.3389/fnins.2021.715330

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Gary S. Goldfield, Jeremy Walsh, Ronald J. Sigal, Glen P. Kenny, Stasia Hadjiyannakis, Michael De Lisio, Mathew Ngu, Denis Prud’homme, Angela S. Alberga, Steve Doucette, Diana B. Goldfield, Jameason D. Cameron

Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein (p = 0.01) and fat (p = 0.05) intake, C-Reactive protein (p = 0.05), and a trend toward higher overall energy intake (p = 0.07), fat-free mass (p = 0.07), and lower HDL-C (p = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence. Clinical Trial Registration: http://clinicaltrials.gov/, identifier NCT00195858.

Original language	English
Article number	715330
Journal	Frontiers in Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fnins.2021.715330
Publication status	Published - Nov 12 2021

Bibliographical note

Funding Information:
GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award.

Funding Information:
GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children?s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award.

Publisher Copyright:
Copyright © 2021 Goldfield, Walsh, Sigal, Kenny, Hadjiyannakis, De Lisio, Ngu, Prud’homme, Alberga, Doucette, Goldfield and Cameron.

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fnins.2021.715330

Cite this

Goldfield, G. S., Walsh, J., Sigal, R. J., Kenny, G. P., Hadjiyannakis, S., De Lisio, M., Ngu, M., Prud’homme, D., Alberga, A. S., Doucette, S., Goldfield, D. B., & Cameron, J. D. (2021). Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study. Frontiers in Neuroscience, 15, Article 715330. https://doi.org/10.3389/fnins.2021.715330

Goldfield, GS, Walsh, J, Sigal, RJ, Kenny, GP, Hadjiyannakis, S, De Lisio, M, Ngu, M, Prud’homme, D, Alberga, AS, Doucette, S, Goldfield, DB & Cameron, JD 2021, 'Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study', Frontiers in Neuroscience, vol. 15, 715330. https://doi.org/10.3389/fnins.2021.715330

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title = "Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study",

abstract = "The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein (p = 0.01) and fat (p = 0.05) intake, C-Reactive protein (p = 0.05), and a trend toward higher overall energy intake (p = 0.07), fat-free mass (p = 0.07), and lower HDL-C (p = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence. Clinical Trial Registration: http://clinicaltrials.gov/, identifier NCT00195858.",

author = "Goldfield, {Gary S.} and Jeremy Walsh and Sigal, {Ronald J.} and Kenny, {Glen P.} and Stasia Hadjiyannakis and {De Lisio}, Michael and Mathew Ngu and Denis Prud{\textquoteright}homme and Alberga, {Angela S.} and Steve Doucette and Goldfield, {Diana B.} and Cameron, {Jameason D.}",

note = "Funding Information: GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children{\textquoteright}s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award. Funding Information: GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children?s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award. Publisher Copyright: Copyright {\textcopyright} 2021 Goldfield, Walsh, Sigal, Kenny, Hadjiyannakis, De Lisio, Ngu, Prud{\textquoteright}homme, Alberga, Doucette, Goldfield and Cameron.",

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AU - Walsh, Jeremy

AU - Sigal, Ronald J.

AU - Kenny, Glen P.

AU - Hadjiyannakis, Stasia

AU - De Lisio, Michael

AU - Ngu, Mathew

AU - Prud’homme, Denis

AU - Alberga, Angela S.

AU - Doucette, Steve

AU - Goldfield, Diana B.

AU - Cameron, Jameason D.

N1 - Funding Information: GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award. Funding Information: GG was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children?s Hospital of Eastern Ontario Volunteer Association Board. RS was supported by a Health Senior Scholar award from Alberta Innovates-Health Solutions and was previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. GK was supported by a University Research Chair from the University of Ottawa. AA was supported by a Doctoral Student Research Award from the Canadian Diabetes Association and currently by a FRQ-S Chercheur Boursier Junior 1 Award. Publisher Copyright: Copyright © 2021 Goldfield, Walsh, Sigal, Kenny, Hadjiyannakis, De Lisio, Ngu, Prud’homme, Alberga, Doucette, Goldfield and Cameron.

PY - 2021/11/12

Y1 - 2021/11/12

N2 - The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein (p = 0.01) and fat (p = 0.05) intake, C-Reactive protein (p = 0.05), and a trend toward higher overall energy intake (p = 0.07), fat-free mass (p = 0.07), and lower HDL-C (p = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence. Clinical Trial Registration: http://clinicaltrials.gov/, identifier NCT00195858.

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Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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