Auto-immune lymphoproliferative disorder and other secondary immune thrombocytopenias in childhood

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11 Citations (Scopus)

Abstract

Primary immune thrombocytopenia (ITP) in childhood, typically presents as an acute self-limiting illness. However, secondary ITP is often a chronic disorder due to an underlying disease. Combined cytopenias in childhood, that is, secondary ITP occurring with auto-immune hemolytic anemia and/or auto-immune neutropenia, are often associated with disorders characterized by immune dysregulation. Such disorders include systemic lupus erythematosus, auto-immune lymphoproliferative syndrome, and common variable immune deficiency. Evans syndrome describes the combination of ITP, autoimmune hemolytic anemia, and/or autoimmune neutropenia. However, it is now clear that some patients with Evans syndrome have an underlying immunodeficiency. This report focuses on combined auto-immune cytopenias and highlights the challenges in their diagnosis and management.

Original languageEnglish
Pages (from-to)S12-S14
JournalPediatric Blood and Cancer
Volume60
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2013

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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