Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis

Zeina Al-Mansour; Hongli Li; James R. Cook; Louis S. Constine; Stephen Couban; Douglas A. Stewart; Thomas C. Shea; Pierluigi Porcu; Jane N. Winter; Brad S. Kahl; Sonali M. Smith; Deborah C. Marcellus; Kevin P. Barton; Glenn M. Mills; Michael LeBlanc; Lisa M. Rimsza; Stephen J. Forman; John P. Leonard; Richard I. Fisher; Jonathan W. Friedberg; Patrick J. Stiff

doi:10.1080/10428194.2018.1563691

Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis

Zeina Al-Mansour, Hongli Li, James R. Cook, Louis S. Constine, Stephen Couban, Douglas A. Stewart, Thomas C. Shea, Pierluigi Porcu, Jane N. Winter, Brad S. Kahl, Sonali M. Smith, Deborah C. Marcellus, Kevin P. Barton, Glenn M. Mills, Michael LeBlanc, Lisa M. Rimsza, Stephen J. Forman, John P. Leonard, Richard I. Fisher, Jonathan W. FriedbergPatrick J. Stiff

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed.

Original language	English
Pages (from-to)	1934-1941
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	60
Issue number	8
DOIs	https://doi.org/10.1080/10428194.2018.1563691
Publication status	Published - Jul 3 2019
Externally published	Yes

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: CA180888, CA180819, CA180820, CA180821, CA180863, CCSRI #021039; legacy grants CA46282, CA04919, CA11083, CA58658, CA46368, CA13612; and in part by Bristol-Myers Squibb. The content is solely the responsibility of the authors and does not necessarily represent the official views of either the National Institutes of Health or Bristol-Myers Squibb.

Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

ASJC Scopus Subject Areas

Hematology
Oncology
Cancer Research

PubMed: MeSH publication types

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2018.1563691

Cite this

Al-Mansour, Z., Li, H., Cook, J. R., Constine, L. S., Couban, S., Stewart, D. A., Shea, T. C., Porcu, P., Winter, J. N., Kahl, B. S., Smith, S. M., Marcellus, D. C., Barton, K. P., Mills, G. M., LeBlanc, M., Rimsza, L. M., Forman, S. J., Leonard, J. P., Fisher, R. I., ... Stiff, P. J. (2019). Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis. Leukemia and Lymphoma, 60(8), 1934-1941. https://doi.org/10.1080/10428194.2018.1563691

Al-Mansour, Z, Li, H, Cook, JR, Constine, LS, Couban, S, Stewart, DA, Shea, TC, Porcu, P, Winter, JN, Kahl, BS, Smith, SM, Marcellus, DC, Barton, KP, Mills, GM, LeBlanc, M, Rimsza, LM, Forman, SJ, Leonard, JP, Fisher, RI, Friedberg, JW & Stiff, PJ 2019, 'Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis', Leukemia and Lymphoma, vol. 60, no. 8, pp. 1934-1941. https://doi.org/10.1080/10428194.2018.1563691

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title = "Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis",

abstract = "Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed.",

author = "Zeina Al-Mansour and Hongli Li and Cook, {James R.} and Constine, {Louis S.} and Stephen Couban and Stewart, {Douglas A.} and Shea, {Thomas C.} and Pierluigi Porcu and Winter, {Jane N.} and Kahl, {Brad S.} and Smith, {Sonali M.} and Marcellus, {Deborah C.} and Barton, {Kevin P.} and Mills, {Glenn M.} and Michael LeBlanc and Rimsza, {Lisa M.} and Forman, {Stephen J.} and Leonard, {John P.} and Fisher, {Richard I.} and Friedberg, {Jonathan W.} and Stiff, {Patrick J.}",

note = "Funding Information: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: CA180888, CA180819, CA180820, CA180821, CA180863, CCSRI #021039; legacy grants CA46282, CA04919, CA11083, CA58658, CA46368, CA13612; and in part by Bristol-Myers Squibb. The content is solely the responsibility of the authors and does not necessarily represent the official views of either the National Institutes of Health or Bristol-Myers Squibb. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

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AU - Al-Mansour, Zeina

AU - Li, Hongli

AU - Cook, James R.

AU - Constine, Louis S.

AU - Couban, Stephen

AU - Stewart, Douglas A.

AU - Shea, Thomas C.

AU - Porcu, Pierluigi

AU - Winter, Jane N.

AU - Kahl, Brad S.

AU - Smith, Sonali M.

AU - Marcellus, Deborah C.

AU - Barton, Kevin P.

AU - Mills, Glenn M.

AU - LeBlanc, Michael

AU - Rimsza, Lisa M.

AU - Forman, Stephen J.

AU - Leonard, John P.

AU - Fisher, Richard I.

AU - Friedberg, Jonathan W.

AU - Stiff, Patrick J.

N1 - Funding Information: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: CA180888, CA180819, CA180820, CA180821, CA180863, CCSRI #021039; legacy grants CA46282, CA04919, CA11083, CA58658, CA46368, CA13612; and in part by Bristol-Myers Squibb. The content is solely the responsibility of the authors and does not necessarily represent the official views of either the National Institutes of Health or Bristol-Myers Squibb. Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2019/7/3

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N2 - Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed.

AB - Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed.

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Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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