Abstract
Besides serving as a structural membrane component and intermediate of the glycerolipid metabolism, lysophosphatidic acid (LPA) has a prominent role as a signaling molecule through its binding to LPA receptors at the cell surface. Extracellular LPA is primarily produced from lysophosphatidylcholine (LPC) through the activity of secreted lysophospholipase D, autotaxin (ATX). The degradation of extracellular LPA to monoacylglycerol is mediated by lipid phosphate phosphatases (LPPs) at the cell membrane. This review summarizes and interprets current literature on the role of the ATX-LPA-LPP3 axis in the regulation of energy homeostasis, insulin function, and adiposity at baseline and under conditions of obesity. We also discuss how the ATX-LPA-LPP3 axis influences obesity-related metabolic complications, including insulin resistance, fatty liver disease, and cardiomyopathy.
| Original language | English |
|---|---|
| Article number | 9575 |
| Journal | International Journal of Molecular Sciences |
| Volume | 22 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Sept 2021 |
Bibliographical note
Funding Information:Funding: This research was funded by the Canadian Institutes of Health Research, grant number 156308, the Natural Sciences and Engineering Research Council of Canada, grant number RGPIN 2020-04883, and the Hearth and Stroke Foundation of Canada, National New Investigator Award. The APC was funded by the Canadian Institutes of Health Research.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ASJC Scopus Subject Areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
PubMed: MeSH publication types
- Journal Article
- Review
