Bilateral ablation of the corticostriatal projection: Behavioral, biochemical and electrophysiological correlates

Marcus W. Warenycia; Gerald M. McKenzie; Mary G. Murphy; John G. Szerb

doi:10.1016/0278-5846(84)90054-X

Bilateral ablation of the corticostriatal projection: Behavioral, biochemical and electrophysiological correlates

Marcus W. Warenycia, Gerald M. McKenzie, Mary G. Murphy, John G. Szerb

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1. Striatal neuronal responses to dexamphetamine, 2.5 mg/kg i.p., were examined in normal and bilateral cortically ablated freely moving rats using multiunit recording. 2. Striatal glutamate levels, D₁ and D₂ receptor binding, and haloperidal catalepsy were examined in both sham-operated and ablated animals. 3. Bilateral ablation of the cortex, while not affecting dexamphetamine-induced behavioral activation, changed the Striatal neuronal response from predominantly excitation to inhibition. Striatal glutamate levels were reduced 22% in ablated animals; and dopamine D-2 receptor binding sites were similarly decreased by 20%. In bilaterally ablated animals, haloperidol-induced catalepsy was greatly reduced.

Original language	English
Pages (from-to)	761-764
Number of pages	4
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	8
Issue number	4-6
DOIs	https://doi.org/10.1016/0278-5846(84)90054-X
Publication status	Published - 1984

Bibliographical note

Funding Information:
The authors gratefully acknowledge the expert technical assistance of ds. Hanni Taylor, Ms. PLa Pehtla and fir. Patrick O'Regan. This work was supported by the Dalhousie Medical Faculty Kesearch Fund and the NRC.

ASJC Scopus Subject Areas

Pharmacology
Biological Psychiatry

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10.1016/0278-5846(84)90054-X

Cite this

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title = "Bilateral ablation of the corticostriatal projection: Behavioral, biochemical and electrophysiological correlates",

abstract = "1. Striatal neuronal responses to dexamphetamine, 2.5 mg/kg i.p., were examined in normal and bilateral cortically ablated freely moving rats using multiunit recording. 2. Striatal glutamate levels, D1 and D2 receptor binding, and haloperidal catalepsy were examined in both sham-operated and ablated animals. 3. Bilateral ablation of the cortex, while not affecting dexamphetamine-induced behavioral activation, changed the Striatal neuronal response from predominantly excitation to inhibition. Striatal glutamate levels were reduced 22% in ablated animals; and dopamine D-2 receptor binding sites were similarly decreased by 20%. In bilaterally ablated animals, haloperidol-induced catalepsy was greatly reduced.",

author = "Warenycia, {Marcus W.} and McKenzie, {Gerald M.} and Murphy, {Mary G.} and Szerb, {John G.}",

note = "Funding Information: The authors gratefully acknowledge the expert technical assistance of ds. Hanni Taylor, Ms. PLa Pehtla and fir. Patrick O'Regan. This work was supported by the Dalhousie Medical Faculty Kesearch Fund and the NRC.",

year = "1984",

doi = "10.1016/0278-5846(84)90054-X",

language = "English",

volume = "8",

pages = "761--764",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "4-6",

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T1 - Bilateral ablation of the corticostriatal projection

T2 - Behavioral, biochemical and electrophysiological correlates

AU - Warenycia, Marcus W.

AU - McKenzie, Gerald M.

AU - Murphy, Mary G.

AU - Szerb, John G.

N1 - Funding Information: The authors gratefully acknowledge the expert technical assistance of ds. Hanni Taylor, Ms. PLa Pehtla and fir. Patrick O'Regan. This work was supported by the Dalhousie Medical Faculty Kesearch Fund and the NRC.

PY - 1984

Y1 - 1984

N2 - 1. Striatal neuronal responses to dexamphetamine, 2.5 mg/kg i.p., were examined in normal and bilateral cortically ablated freely moving rats using multiunit recording. 2. Striatal glutamate levels, D1 and D2 receptor binding, and haloperidal catalepsy were examined in both sham-operated and ablated animals. 3. Bilateral ablation of the cortex, while not affecting dexamphetamine-induced behavioral activation, changed the Striatal neuronal response from predominantly excitation to inhibition. Striatal glutamate levels were reduced 22% in ablated animals; and dopamine D-2 receptor binding sites were similarly decreased by 20%. In bilaterally ablated animals, haloperidol-induced catalepsy was greatly reduced.

AB - 1. Striatal neuronal responses to dexamphetamine, 2.5 mg/kg i.p., were examined in normal and bilateral cortically ablated freely moving rats using multiunit recording. 2. Striatal glutamate levels, D1 and D2 receptor binding, and haloperidal catalepsy were examined in both sham-operated and ablated animals. 3. Bilateral ablation of the cortex, while not affecting dexamphetamine-induced behavioral activation, changed the Striatal neuronal response from predominantly excitation to inhibition. Striatal glutamate levels were reduced 22% in ablated animals; and dopamine D-2 receptor binding sites were similarly decreased by 20%. In bilaterally ablated animals, haloperidol-induced catalepsy was greatly reduced.

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AN - SCOPUS:0021685594

SN - 0278-5846

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JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 4-6

ER -

Bilateral ablation of the corticostriatal projection: Behavioral, biochemical and electrophysiological correlates

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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