Biology of RUNX2 and cleidocranial dysplasia

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24 Citations (Scopus)

Abstract

Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities. These are derived from endochondral and intramembranous ossification, but the distinction between these 2 processes is oversimplified because both processes are involved in long bone and clavicular development. Two sections follow: the biology of RUNX2 and the nature of haploinsufficiency in RUNX2 mutations for cleidocranial dysplasia.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalJournal of Craniofacial Surgery
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 2013

ASJC Scopus Subject Areas

  • Surgery
  • Otorhinolaryngology

PubMed: MeSH publication types

  • Journal Article
  • Review

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Cohen, M. M. (2013). Biology of RUNX2 and cleidocranial dysplasia. Journal of Craniofacial Surgery, 24(1), 130-133. https://doi.org/10.1097/SCS.0b013e3182636b7e