Abstract
Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities. These are derived from endochondral and intramembranous ossification, but the distinction between these 2 processes is oversimplified because both processes are involved in long bone and clavicular development. Two sections follow: the biology of RUNX2 and the nature of haploinsufficiency in RUNX2 mutations for cleidocranial dysplasia.
Original language | English |
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Pages (from-to) | 130-133 |
Number of pages | 4 |
Journal | Journal of Craniofacial Surgery |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2013 |
ASJC Scopus Subject Areas
- Surgery
- Otorhinolaryngology
PubMed: MeSH publication types
- Journal Article
- Review
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Cohen, M. M. (2013). Biology of RUNX2 and cleidocranial dysplasia. Journal of Craniofacial Surgery, 24(1), 130-133. https://doi.org/10.1097/SCS.0b013e3182636b7e