Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines

D. Taub, J. Dastych, N. Inamura, J. Upton, D. Kelvin, D. Metcalfe, J. Oppenheim

Research output: Contribution to journalArticlepeer-review

127 Citations (Scopus)

Abstract

We have determined that several chemokines induce mast cell migration in vitro. This directed migration is dependent on the presence of particular extracellular matrix proteins and the activation status of the cells. Mast cell haptotactic responses were observed in response to various chemokines on vitronectin-, laminin-, and fibronectin-coated filters. Unstimulated mast cells were chemoattracted only by monocyte chemotactic protein-1 and RANTES on vitronectin-coated and, to a lesser extent, laminin-coated filters, whereas IgE-activated mast cells migrated in response to monocyte chemotactic protein-1, regulated on activation normal T expressed and secreted, platelet factor-4, and macrophage inflammatory protein-1α on all three matrix proteins. No significant migration was observed on collagen type IV-coated or uncoated filters. Mast cell migration in response to chemokines on extracellular matrices and its enhancement by IgE-dependent activation provide a mechanism by which cells may be drawn to sites of inflammation. Chemokine-induced mast cell recruitment may be particularly relevant in host defense responses to parasitic infections, allergic reactions, Jones-Mote reactions, and in wound healing.

Original languageEnglish
Pages (from-to)2393-2402
Number of pages10
JournalJournal of Immunology
Volume154
Issue number5
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

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