Caffeine as an Adjuvant to Ibuprofen in Treating Childhood Headaches

Joseph M. Dooley; Kevin E. Gordon; Ellen P. Wood; Paula M. Brna; Judith MacSween; Alex Fraser

doi:10.1016/j.pediatrneurol.2007.02.016

Caffeine as an Adjuvant to Ibuprofen in Treating Childhood Headaches

Joseph M. Dooley, Kevin E. Gordon, Ellen P. Wood, Paula M. Brna, Judith MacSween, Alex Fraser

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

In adults, caffeine has been shown to enhance the effectiveness of most analgesics, including ibuprofen. This double-blind cross-over pilot study evaluated the effect of ibuprofen and caffeine compared with ibuprofen and placebo in 12 children with headaches. Patients completed diaries for both headaches. Outcome measures included a five-faces severity scale, a measure of clinical disability, and a scale of pain severity. Comparison of the cumulative response scores revealed a trend toward a greater response to ibuprofen-caffeine treatment of headaches (P = 0.14, P = 0.09, and P = 0.07 for the three measures, respectively). Further larger studies are needed to confirm this effect and to identify potential responders.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	Pediatric Neurology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.pediatrneurol.2007.02.016
Publication status	Published - Jul 2007

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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10.1016/j.pediatrneurol.2007.02.016

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abstract = "In adults, caffeine has been shown to enhance the effectiveness of most analgesics, including ibuprofen. This double-blind cross-over pilot study evaluated the effect of ibuprofen and caffeine compared with ibuprofen and placebo in 12 children with headaches. Patients completed diaries for both headaches. Outcome measures included a five-faces severity scale, a measure of clinical disability, and a scale of pain severity. Comparison of the cumulative response scores revealed a trend toward a greater response to ibuprofen-caffeine treatment of headaches (P = 0.14, P = 0.09, and P = 0.07 for the three measures, respectively). Further larger studies are needed to confirm this effect and to identify potential responders.",

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AU - Wood, Ellen P.

AU - Brna, Paula M.

AU - MacSween, Judith

AU - Fraser, Alex

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AB - In adults, caffeine has been shown to enhance the effectiveness of most analgesics, including ibuprofen. This double-blind cross-over pilot study evaluated the effect of ibuprofen and caffeine compared with ibuprofen and placebo in 12 children with headaches. Patients completed diaries for both headaches. Outcome measures included a five-faces severity scale, a measure of clinical disability, and a scale of pain severity. Comparison of the cumulative response scores revealed a trend toward a greater response to ibuprofen-caffeine treatment of headaches (P = 0.14, P = 0.09, and P = 0.07 for the three measures, respectively). Further larger studies are needed to confirm this effect and to identify potential responders.

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Caffeine as an Adjuvant to Ibuprofen in Treating Childhood Headaches

Abstract

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