Abstract
Objective: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Methods: Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Results: Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent-onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Conclusion: Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD.
Original language | English |
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Pages (from-to) | 468-476 |
Number of pages | 9 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 140 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1 2019 |
Bibliographical note
Funding Information:This study was supported by public funding from Agence Nationale de la Recherche (ANR‐11‐IDEX‐0004, ANR‐11‐INBS‐006, ANR‐14‐CE35‐0035, ANR MNP VIP 2008), Deutsche Forschungsgemeinschaft (SFB636/C6 and We3638/3‐1), Ministerstvo Zdravotnictví Ceské Republiky (NV16‐32696A and NV16‐32791A), National Institute of Mental Health (R01 MH076971) and Regione Veneto Italy (159/03, DGRV n. 4087).
Funding Information:
This study was supported by public funding from Agence Nationale de la Recherche (ANR-11-IDEX-0004, ANR-11-INBS-006, ANR-14-CE35-0035, ANR MNP VIP 2008), Deutsche Forschungsgemeinschaft (SFB636/C6 and We3638/3-1), Ministerstvo Zdravotnictv? Cesk? Republiky (NV16-32696A?and?NV16-32791A), National Institute of Mental Health (R01 MH076971) and Regione Veneto Italy (159/03, DGRV n. 4087). We thank all subjects for their participation in this study. CL wrote the main manuscript text and prepared Figures and Tables. PC processed the anatomical images. All authors reviewed the manuscript.
Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ASJC Scopus Subject Areas
- Psychiatry and Mental health