Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development

Sascha K. Hooker; Tracy L. Metcalfe; Chris D. Metcalfe; Carolyn M. Angell; Joanna Y. Wilson; Michael J. Moore; Hal Whitehead

doi:10.1016/j.envpol.2007.05.027

Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development

Sascha K. Hooker, Tracy L. Metcalfe, Chris D. Metcalfe, Carolyn M. Angell, Joanna Y. Wilson, Michael J. Moore, Hal Whitehead

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A small population of endangered northern bottlenose whales (Hyperoodon ampullatus) inhabits "The Gully" a Marine Protected Area on the Scotian Shelf, eastern Canada. Amid concerns regarding nearby oil and gas development, we took 36 skin and blubber biopsy samples in 1996-1997 (prior to major development) and 2002-2003 (five years after development began), and three samples from a population in the Davis Strait, Labrador in 2003. These were analysed for cytochrome P4501A1 (CYP1A1) protein expression (n = 36), and for persistent contaminants (n = 23). CYP1A1 showed generally low expression in whales from The Gully, but higher levels during 2003, potentially coincident with recorded oil spills, and higher levels in Davis Strait whales. A range of PCB congeners and organochlorine compounds were detected, with concentrations similar to other North Atlantic odontocetes. Concentrations were higher in whales from The Gully than from the Davis Strait, with significant increases in 4,4′-DDE and trans-nonachlor in 2002-2003 relative to 1996-1997.

Original language	English
Pages (from-to)	205-216
Number of pages	12
Journal	Environmental Pollution
Volume	152
Issue number	1
DOIs	https://doi.org/10.1016/j.envpol.2007.05.027
Publication status	Published - Mar 2008

Bibliographical note

Funding Information:
We are grateful to all the crew members of the Balaena, particularly Merel Dalebout, who participated in fieldwork in The Gully and the Davis Strait, and to Phil Clapham and other crew members of the NOAA vessel Delaware II, who facilitated fieldwork in The Gully during 2002. Dr. M.L. Dalebout genotyped the biopsy samples to obtain data on the sexes of whales sampled. Dr. S. Gowans and T. Wimmer provided details on whale ID from photographs taken during biopsy sampling. Research was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada, World Wildlife Fund Canada Endangered Species Recovery Fund, Fisheries and Oceans Canada, the National Geographic Society, the Canadian Federation of Humane Societies and two UK Royal Society International Collaborative Awards. S.K.H. was supported by a Canadian Commonwealth Scholarship and Royal Society Dorothy Hodgkin Research Fellowship. C.D.M. was awarded a Discovery grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada. J.Y.W. was supported by an NSERC PGS B fellowship and the Woods Hole Oceanographic Institution. A. J. Hall kindly reviewed the manuscript.

ASJC Scopus Subject Areas

Toxicology
Pollution
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hooker, S. K., Metcalfe, T. L., Metcalfe, C. D., Angell, C. M., Wilson, J. Y., Moore, M. J., & Whitehead, H. (2008). Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development. Environmental Pollution, 152(1), 205-216. https://doi.org/10.1016/j.envpol.2007.05.027

Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development. / Hooker, Sascha K.; Metcalfe, Tracy L.; Metcalfe, Chris D. et al.
In: Environmental Pollution, Vol. 152, No. 1, 03.2008, p. 205-216.

Research output: Contribution to journal › Article › peer-review

Hooker, SK, Metcalfe, TL, Metcalfe, CD, Angell, CM, Wilson, JY, Moore, MJ & Whitehead, H 2008, 'Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development', Environmental Pollution, vol. 152, no. 1, pp. 205-216. https://doi.org/10.1016/j.envpol.2007.05.027

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abstract = "A small population of endangered northern bottlenose whales (Hyperoodon ampullatus) inhabits {"}The Gully{"} a Marine Protected Area on the Scotian Shelf, eastern Canada. Amid concerns regarding nearby oil and gas development, we took 36 skin and blubber biopsy samples in 1996-1997 (prior to major development) and 2002-2003 (five years after development began), and three samples from a population in the Davis Strait, Labrador in 2003. These were analysed for cytochrome P4501A1 (CYP1A1) protein expression (n = 36), and for persistent contaminants (n = 23). CYP1A1 showed generally low expression in whales from The Gully, but higher levels during 2003, potentially coincident with recorded oil spills, and higher levels in Davis Strait whales. A range of PCB congeners and organochlorine compounds were detected, with concentrations similar to other North Atlantic odontocetes. Concentrations were higher in whales from The Gully than from the Davis Strait, with significant increases in 4,4′-DDE and trans-nonachlor in 2002-2003 relative to 1996-1997.",

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note = "Funding Information: We are grateful to all the crew members of the Balaena, particularly Merel Dalebout, who participated in fieldwork in The Gully and the Davis Strait, and to Phil Clapham and other crew members of the NOAA vessel Delaware II, who facilitated fieldwork in The Gully during 2002. Dr. M.L. Dalebout genotyped the biopsy samples to obtain data on the sexes of whales sampled. Dr. S. Gowans and T. Wimmer provided details on whale ID from photographs taken during biopsy sampling. Research was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada, World Wildlife Fund Canada Endangered Species Recovery Fund, Fisheries and Oceans Canada, the National Geographic Society, the Canadian Federation of Humane Societies and two UK Royal Society International Collaborative Awards. S.K.H. was supported by a Canadian Commonwealth Scholarship and Royal Society Dorothy Hodgkin Research Fellowship. C.D.M. was awarded a Discovery grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada. J.Y.W. was supported by an NSERC PGS B fellowship and the Woods Hole Oceanographic Institution. A. J. Hall kindly reviewed the manuscript.",

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AU - Moore, Michael J.

AU - Whitehead, Hal

N1 - Funding Information: We are grateful to all the crew members of the Balaena, particularly Merel Dalebout, who participated in fieldwork in The Gully and the Davis Strait, and to Phil Clapham and other crew members of the NOAA vessel Delaware II, who facilitated fieldwork in The Gully during 2002. Dr. M.L. Dalebout genotyped the biopsy samples to obtain data on the sexes of whales sampled. Dr. S. Gowans and T. Wimmer provided details on whale ID from photographs taken during biopsy sampling. Research was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada, World Wildlife Fund Canada Endangered Species Recovery Fund, Fisheries and Oceans Canada, the National Geographic Society, the Canadian Federation of Humane Societies and two UK Royal Society International Collaborative Awards. S.K.H. was supported by a Canadian Commonwealth Scholarship and Royal Society Dorothy Hodgkin Research Fellowship. C.D.M. was awarded a Discovery grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada. J.Y.W. was supported by an NSERC PGS B fellowship and the Woods Hole Oceanographic Institution. A. J. Hall kindly reviewed the manuscript.

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Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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