Abstract
The objective of this research project was to evaluate the potential use of chitosan (CS) nanoparticles (NPs) as a drug delivery system for the molecule adenosine. Adenosine is an essential drug used for treating several health issues especially irregular heart rhythm. However, due to its extremely short half-life in vivo (<10 s), the effective delivery of adenosine in clinical applications is a significant challenge. In this research, adenosine was encapsulated into NPs formed by ionic gelation of CS. The encapsulation efficiency and loading capacity of 20% and 3% were obtained, respectively, by forming a complex between CS NPs and adenosine. The obtained CS NPs had a spherical shape in the size range of 260.6 ± 20.1 nm. Spectrophotometry analysis of the adenosine released in vitro showed an initial burst release phase, a plateau phase, followed by a steady release over a week.
| Original language | English |
|---|---|
| Pages (from-to) | 460-466 |
| Number of pages | 7 |
| Journal | Journal of Microencapsulation |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 4 2015 |
Bibliographical note
Publisher Copyright:© 2015 Informa UK Ltd. All rights reserved.
ASJC Scopus Subject Areas
- Bioengineering
- Pharmaceutical Science
- Physical and Theoretical Chemistry
- Organic Chemistry
- Colloid and Surface Chemistry
PubMed: MeSH publication types
- Journal Article