Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

for the BBOP Study Group

doi:10.1186/s12969-021-00584-4

Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

for the BBOP Study Group

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the 2 years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA). Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores. Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score − 0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r = − 0.251; p = 0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4–3.1) to 24 months (median and IQR: 2.1, 1.4–2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p < 0.001). Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.

Original language	English
Article number	97
Journal	Pediatric Rheumatology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12969-021-00584-4
Publication status	Published - Dec 2021
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by funding from the Canadian Institutes for Health Research (Institute of Musculoskeletal Health and Arthritis and Institute of Infection and Immunity), The Arthritis Society, The Canadian Arthritis Network, The University of Saskatchewan, The Manitoba Institute of Child Health, McGill University (Division of Pediatric Rheumatology), Memorial University, The University of British Columbia (Division of Pediatric Rheumatology), The Clinical Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, The Haslam Fund (University of Saskatchewan), The Kleiman Fund (University of Saskatchewan). The Pediatric Bone Mineral Accrual Study was supported by funding from the Canadian Institutes for Health Research, the Saskatchewan Health Research Foundation, Dairy Farmers of Canada, and the University of Saskatchewan.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Rheumatology

PubMed: MeSH publication types

Journal Article
Multicenter Study

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10.1186/s12969-021-00584-4

Cite this

@article{de7c6dc67e3846e2b761cf879c0d969b,

title = "Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis",

abstract = "Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the 2 years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA). Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores. Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score − 0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r = − 0.251; p = 0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4–3.1) to 24 months (median and IQR: 2.1, 1.4–2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p < 0.001). Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.",

author = "{for the BBOP Study Group} and Heale, {Liane D.} and Houghton, {Kristin M.} and Elham Rezaei and Baxter-Jones, {Adam D.G.} and Tupper, {Susan M.} and Nazeem Muhajarine and Benseler, {Susanne M.} and Gilles Boire and Cabral, {David A.} and Sarah Campillo and Ga{\"e}lle Ch{\'e}deville and Chetaille, {Anne Laure} and Paul Dancey and Ciaran Duffy and Duffy, {Karen Watanabe} and Janet Ellsworth and Jaime Guzman and Huber, {Adam M.} and Roman Jurencak and Bianca Lang and Laxer, {Ronald M.} and Kimberly Morishita and Oen, {Kiem G.} and Petty, {Ross E.} and Ramsey, {Suzanne E.} and Johannes Roth and Rayfel Schneider and Rosie Scuccimarri and Lynn Spiegel and Elizabeth Stringer and Tse, {Shirley M.L.} and Tucker, {Lori B.} and Turvey, {Stuart E.} and Yeung, {Rae S.M.} and Rosenberg, {Alan M.}",

note = "Funding Information: This research was supported by funding from the Canadian Institutes for Health Research (Institute of Musculoskeletal Health and Arthritis and Institute of Infection and Immunity), The Arthritis Society, The Canadian Arthritis Network, The University of Saskatchewan, The Manitoba Institute of Child Health, McGill University (Division of Pediatric Rheumatology), Memorial University, The University of British Columbia (Division of Pediatric Rheumatology), The Clinical Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, The Haslam Fund (University of Saskatchewan), The Kleiman Fund (University of Saskatchewan). The Pediatric Bone Mineral Accrual Study was supported by funding from the Canadian Institutes for Health Research, the Saskatchewan Health Research Foundation, Dairy Farmers of Canada, and the University of Saskatchewan. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s12969-021-00584-4",

language = "English",

volume = "19",

journal = "Pediatric Rheumatology",

issn = "1546-0096",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

AU - for the BBOP Study Group

AU - Heale, Liane D.

AU - Houghton, Kristin M.

AU - Rezaei, Elham

AU - Baxter-Jones, Adam D.G.

AU - Tupper, Susan M.

AU - Muhajarine, Nazeem

AU - Benseler, Susanne M.

AU - Boire, Gilles

AU - Cabral, David A.

AU - Campillo, Sarah

AU - Chédeville, Gaëlle

AU - Chetaille, Anne Laure

AU - Dancey, Paul

AU - Duffy, Ciaran

AU - Duffy, Karen Watanabe

AU - Ellsworth, Janet

AU - Guzman, Jaime

AU - Huber, Adam M.

AU - Jurencak, Roman

AU - Lang, Bianca

AU - Laxer, Ronald M.

AU - Morishita, Kimberly

AU - Oen, Kiem G.

AU - Petty, Ross E.

AU - Ramsey, Suzanne E.

AU - Roth, Johannes

AU - Schneider, Rayfel

AU - Scuccimarri, Rosie

AU - Spiegel, Lynn

AU - Stringer, Elizabeth

AU - Tse, Shirley M.L.

AU - Tucker, Lori B.

AU - Turvey, Stuart E.

AU - Yeung, Rae S.M.

AU - Rosenberg, Alan M.

N1 - Funding Information: This research was supported by funding from the Canadian Institutes for Health Research (Institute of Musculoskeletal Health and Arthritis and Institute of Infection and Immunity), The Arthritis Society, The Canadian Arthritis Network, The University of Saskatchewan, The Manitoba Institute of Child Health, McGill University (Division of Pediatric Rheumatology), Memorial University, The University of British Columbia (Division of Pediatric Rheumatology), The Clinical Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, The Haslam Fund (University of Saskatchewan), The Kleiman Fund (University of Saskatchewan). The Pediatric Bone Mineral Accrual Study was supported by funding from the Canadian Institutes for Health Research, the Saskatchewan Health Research Foundation, Dairy Farmers of Canada, and the University of Saskatchewan. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the 2 years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA). Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores. Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score − 0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r = − 0.251; p = 0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4–3.1) to 24 months (median and IQR: 2.1, 1.4–2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p < 0.001). Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.

AB - Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the 2 years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA). Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores. Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score − 0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r = − 0.251; p = 0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4–3.1) to 24 months (median and IQR: 2.1, 1.4–2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p < 0.001). Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress.

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U2 - 10.1186/s12969-021-00584-4

DO - 10.1186/s12969-021-00584-4

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SN - 1546-0096

VL - 19

JO - Pediatric Rheumatology

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ER -

Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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