Clinical valproate toxicity induced by acetylsalicylic acid

Keith J. Goulden; Joseph M. Dooley; Peter R. Camfield; Albert D. Fraser

doi:10.1212/wnl.37.8.1392

Clinical valproate toxicity induced by acetylsalicylic acid

Keith J. Goulden, Joseph M. Dooley, Peter R. Camfield, Albert D. Fraser

Medicine

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59 Citations (Scopus)

Abstract

We report three patients with serious clinical valproate (VPA) toxicity induced by interaction with acetylsalicylic acid (ASA). Two patients had a documented rise in VP A free level, and the third showed only clinical signs of toxicity. Symptoms resolved in all three when the ASA was stopped. This interaction has been previously documented under experimental conditions, and is due to displacement of VPA from plasma protein binding sites and a probable interference in metabolism. This is the first report of the clinical significance of this interaction.

Original language	English
Pages (from-to)	1392-1394
Number of pages	3
Journal	Neurology
Volume	37
Issue number	8
DOIs	https://doi.org/10.1212/wnl.37.8.1392
Publication status	Published - Aug 1987

ASJC Scopus Subject Areas

Clinical Neurology

PubMed: MeSH publication types

Case Reports
Journal Article

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10.1212/wnl.37.8.1392

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abstract = "We report three patients with serious clinical valproate (VPA) toxicity induced by interaction with acetylsalicylic acid (ASA). Two patients had a documented rise in VP A free level, and the third showed only clinical signs of toxicity. Symptoms resolved in all three when the ASA was stopped. This interaction has been previously documented under experimental conditions, and is due to displacement of VPA from plasma protein binding sites and a probable interference in metabolism. This is the first report of the clinical significance of this interaction.",

author = "Goulden, {Keith J.} and Dooley, {Joseph M.} and Camfield, {Peter R.} and Fraser, {Albert D.}",

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N2 - We report three patients with serious clinical valproate (VPA) toxicity induced by interaction with acetylsalicylic acid (ASA). Two patients had a documented rise in VP A free level, and the third showed only clinical signs of toxicity. Symptoms resolved in all three when the ASA was stopped. This interaction has been previously documented under experimental conditions, and is due to displacement of VPA from plasma protein binding sites and a probable interference in metabolism. This is the first report of the clinical significance of this interaction.

AB - We report three patients with serious clinical valproate (VPA) toxicity induced by interaction with acetylsalicylic acid (ASA). Two patients had a documented rise in VP A free level, and the third showed only clinical signs of toxicity. Symptoms resolved in all three when the ASA was stopped. This interaction has been previously documented under experimental conditions, and is due to displacement of VPA from plasma protein binding sites and a probable interference in metabolism. This is the first report of the clinical significance of this interaction.

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Clinical valproate toxicity induced by acetylsalicylic acid

Abstract

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PubMed: MeSH publication types

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