Co-expression of p75(NTR)- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain

Liisa Tremere; Gert Brückner; Kurt Brauer; Douglas D. Rasmusson; Reinhild Poethke; Wolfgang Härtig

doi:10.1016/S0006-8993(98)00436-3

Co-expression of p75(NTR)- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain

Liisa Tremere, Gert Brückner, Kurt Brauer, Douglas D. Rasmusson, Reinhild Poethke, Wolfgang Härtig

Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The cholinergic system of the basal forebrain is involved in the modulation of sensory information. This has previously been investigated in the raccoon, an animal especially interesting because of its highly developed somatosensory cortex. The present study focused on the co-expression of the low-affinity neurotrophin receptor p75(NTR) and calbindin in cholinergic neurons of the raccoon basal forebrain and neostriatum. Carbocyanine immunofluorescence double labelling revealed the co-localization of choline acetyltransferase and p75(NTR) as well as calbindin in a large portion of basal forebrain neurons, but not in the neostriatum. In contrast, immunolabelling of two other calcium-binding proteins, parvalbumin and calretinin, was found exclusively in non-cholinergic neurons.

Original language	English
Pages (from-to)	351-356
Number of pages	6
Journal	Brain Research
Volume	797
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(98)00436-3
Publication status	Published - Jun 29 1998

Bibliographical note

Funding Information:
We gratefully thank Ute Bauer (Leipzig) for excellent technical assistance and Dr. Alan Fine (Halifax) for providing the monoclonal antibody ME 20.4 directed against p75 NTR . This research was supported by the Medical Research Council of Canada.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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Tremere, L., Brückner, G., Brauer, K., Rasmusson, D. D., Poethke, R., & Härtig, W. (1998). Co-expression of p75(NTR)- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain. Brain Research, 797(2), 351-356. https://doi.org/10.1016/S0006-8993(98)00436-3

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title = "Co-expression of p75(NTR)- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain",

abstract = "The cholinergic system of the basal forebrain is involved in the modulation of sensory information. This has previously been investigated in the raccoon, an animal especially interesting because of its highly developed somatosensory cortex. The present study focused on the co-expression of the low-affinity neurotrophin receptor p75(NTR) and calbindin in cholinergic neurons of the raccoon basal forebrain and neostriatum. Carbocyanine immunofluorescence double labelling revealed the co-localization of choline acetyltransferase and p75(NTR) as well as calbindin in a large portion of basal forebrain neurons, but not in the neostriatum. In contrast, immunolabelling of two other calcium-binding proteins, parvalbumin and calretinin, was found exclusively in non-cholinergic neurons.",

author = "Liisa Tremere and Gert Br{\"u}ckner and Kurt Brauer and Rasmusson, {Douglas D.} and Reinhild Poethke and Wolfgang H{\"a}rtig",

note = "Funding Information: We gratefully thank Ute Bauer (Leipzig) for excellent technical assistance and Dr. Alan Fine (Halifax) for providing the monoclonal antibody ME 20.4 directed against p75 NTR . This research was supported by the Medical Research Council of Canada.",

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AU - Rasmusson, Douglas D.

AU - Poethke, Reinhild

AU - Härtig, Wolfgang

N1 - Funding Information: We gratefully thank Ute Bauer (Leipzig) for excellent technical assistance and Dr. Alan Fine (Halifax) for providing the monoclonal antibody ME 20.4 directed against p75 NTR . This research was supported by the Medical Research Council of Canada.

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Co-expression of p75(NTR)- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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