Concanavalin A in vivo: Induction of hemorrhagic skin lesions (Arthus-like reactions) in mice

Leon S. Kind; Warren A. Petersen

doi:10.1126/science.160.3825.312

Concanavalin A in vivo: Induction of hemorrhagic skin lesions (Arthus-like reactions) in mice

Leon S. Kind, Warren A. Petersen

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Abstract

Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if Concanavalin A was adsorbed with insoluble α₂macroglobulin or if mice were first treated with nitrogen mustard. The ability of Concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

Original language	English
Pages (from-to)	312-313
Number of pages	2
Journal	Science
Volume	160
Issue number	3825
DOIs	https://doi.org/10.1126/science.160.3825.312
Publication status	Published - 1968
Externally published	Yes

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title = "Concanavalin A in vivo: Induction of hemorrhagic skin lesions (Arthus-like reactions) in mice",

abstract = "Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if Concanavalin A was adsorbed with insoluble α2macroglobulin or if mice were first treated with nitrogen mustard. The ability of Concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.",

author = "Kind, {Leon S.} and Petersen, {Warren A.}",

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T2 - Induction of hemorrhagic skin lesions (Arthus-like reactions) in mice

AU - Kind, Leon S.

AU - Petersen, Warren A.

PY - 1968

Y1 - 1968

N2 - Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if Concanavalin A was adsorbed with insoluble α2macroglobulin or if mice were first treated with nitrogen mustard. The ability of Concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

AB - Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if Concanavalin A was adsorbed with insoluble α2macroglobulin or if mice were first treated with nitrogen mustard. The ability of Concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

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ER -

Concanavalin A in vivo: Induction of hemorrhagic skin lesions (Arthus-like reactions) in mice

Abstract

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