Constitutional rearrangements of 7q22 in hematologic malignancies: A new case report

Donna L. Forrest; Christine L.Y. Lee

doi:10.1016/S0165-4608(02)00606-4

Constitutional rearrangements of 7q22 in hematologic malignancies: A new case report

Donna L. Forrest, Christine L.Y. Lee

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Abnormalities of chromosome 7 are a frequent finding in myelocytic malignancies and are associated with a poor prognosis. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and the second in region 7q32∼q35. The chromosomal breakpoint in band 7q22 appears to be heterogeneous and may involve tumor suppressor gene(s). Constitutional rearrangements of 7q22 have rarely been reported in myeloid malignancies. To our knowledge, this is the first report in the literature of a myeloproliferative disorder with a constitutional t(1;7)(q42;q22).

Original language	English
Pages (from-to)	75-77
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	139
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(02)00606-4
Publication status	Published - Nov 2002

ASJC Scopus Subject Areas

Molecular Biology
Genetics
Cancer Research

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10.1016/S0165-4608(02)00606-4

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title = "Constitutional rearrangements of 7q22 in hematologic malignancies: A new case report",

abstract = "Abnormalities of chromosome 7 are a frequent finding in myelocytic malignancies and are associated with a poor prognosis. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and the second in region 7q32∼q35. The chromosomal breakpoint in band 7q22 appears to be heterogeneous and may involve tumor suppressor gene(s). Constitutional rearrangements of 7q22 have rarely been reported in myeloid malignancies. To our knowledge, this is the first report in the literature of a myeloproliferative disorder with a constitutional t(1;7)(q42;q22).",

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AU - Forrest, Donna L.

AU - Lee, Christine L.Y.

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N2 - Abnormalities of chromosome 7 are a frequent finding in myelocytic malignancies and are associated with a poor prognosis. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and the second in region 7q32∼q35. The chromosomal breakpoint in band 7q22 appears to be heterogeneous and may involve tumor suppressor gene(s). Constitutional rearrangements of 7q22 have rarely been reported in myeloid malignancies. To our knowledge, this is the first report in the literature of a myeloproliferative disorder with a constitutional t(1;7)(q42;q22).

AB - Abnormalities of chromosome 7 are a frequent finding in myelocytic malignancies and are associated with a poor prognosis. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and the second in region 7q32∼q35. The chromosomal breakpoint in band 7q22 appears to be heterogeneous and may involve tumor suppressor gene(s). Constitutional rearrangements of 7q22 have rarely been reported in myeloid malignancies. To our knowledge, this is the first report in the literature of a myeloproliferative disorder with a constitutional t(1;7)(q42;q22).

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Constitutional rearrangements of 7q22 in hematologic malignancies: A new case report

Abstract

ASJC Scopus Subject Areas

UN SDGs

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