Coordination between differentially regulated circadian clocks generates rhythmic behavior

Deniz Top, Michael W. Young

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Specialized groups of neurons in the brain are key mediators of circadian rhythms, receiving daily environmental cues and communicating those signals to other tissues in the organism for entrainment and to organize circadian physiology. In Drosophila, the “circadian clock” is housed in seven neuronal clusters, which are defined by their expression of the main circadian proteins, Period, Timeless, Clock, and Cycle. These clusters are distributed across the fly brain and are thereby subject to the respective environments associated with their anatomical locations. While these core components are universally expressed in all neurons of the circadian network, additional regulatory proteins that act on these components are differentially expressed, giving rise to “local clocks” within the network that nonetheless converge to regulate coherent behavioral rhythms. In this review, we describe the communication between the neurons of the circadian network and the molecular differences within neurons of this network. We focus on differences in protein-expression patterns and discuss how such variation can impart functional differences in each local clock. Finally, we summarize our current understanding of how communication within the circadian network intersects with intracellular biochemical mechanisms to ultimately specify behavioral rhythms. We propose that additional efforts are required to identify regulatory mechanisms within each neuronal cluster to understand the molecular basis of circadian behavior.

Original languageEnglish
Article numbera033589
JournalCold Spring Harbor perspectives in biology
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

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Top, D., & Young, M. W. (2018). Coordination between differentially regulated circadian clocks generates rhythmic behavior. Cold Spring Harbor perspectives in biology, 10(7), Article a033589. https://doi.org/10.1101/cshperspect.a033589