TY - JOUR
T1 - Cutting edge
T2 - The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
AU - Al-Alwan, M. M.
AU - Rowden, G.
AU - Lee, T. D.G.
AU - West, K. A.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - The binding of a T cell to an APC results in T cell actin cytoskeletal rearrangement leading to the formation of an immunological synapse. The APC cytoskeleton has been thought to play a passive role in this process. In this study, we demonstrate that dendritic cells (DC), unlike other APC, actively polarize their actin cytoskeleton during interaction with T cells. DC cytoskeletal rearrangement was critical for both the clustering and the activation of resting T cells. This study provides compelling evidence that the APC cytoskeleton plays an active role in the immunological synapse and may explain the unique ability of DC to active resting T cells.
AB - The binding of a T cell to an APC results in T cell actin cytoskeletal rearrangement leading to the formation of an immunological synapse. The APC cytoskeleton has been thought to play a passive role in this process. In this study, we demonstrate that dendritic cells (DC), unlike other APC, actively polarize their actin cytoskeleton during interaction with T cells. DC cytoskeletal rearrangement was critical for both the clustering and the activation of resting T cells. This study provides compelling evidence that the APC cytoskeleton plays an active role in the immunological synapse and may explain the unique ability of DC to active resting T cells.
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U2 - 10.4049/jimmunol.166.3.1452
DO - 10.4049/jimmunol.166.3.1452
M3 - Article
C2 - 11160183
AN - SCOPUS:0035253596
SN - 0022-1767
VL - 166
SP - 1452
EP - 1456
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -