Datasets exploring putative lncRNA-miRNA-mRNA axes in breast cancer cell lines

Marie Claire D. Wasson; Justin M. Brown; Jaganathan Venkatesh; Wasundara Fernando; Paola Marcato

doi:10.1016/j.dib.2021.107241

Datasets exploring putative lncRNA-miRNA-mRNA axes in breast cancer cell lines

Marie Claire D. Wasson, Justin M. Brown, Jaganathan Venkatesh, Wasundara Fernando, Paola Marcato

Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Long non-coding RNA (lncRNA)/microRNA (miRNA)/messenger RNA (mRNA) interactions regulate oncogenesis and tumour suppression in breast cancer. Oncogenic lncRNA/miRNA/mRNA axes may offer novel therapeutic targets; therefore, identifying such axes is a clinically relevant undertaking. To explore miRNAs regulated by oncogenic lncRNAs, we queried the NCBI Gene Expression Omnibus (GEO) database to find datasets that profiled gene expression changes upon lncRNA knockdown in breast cancer. We identified four microarray datasets that permitted our interrogation of genes regulated by lncRNAs LincK, LincIN, SPRY4-IT1 and AC009283.1. We specifically analysed changes in miRNA transcripts within these datasets to study miRNAs regulated by each of the four lncRNAs. We subsequently identified the predicted mRNA targets for these miRNAs to uncover possible lncRNA/miRNA/mRNAs axes in breast cancer. These axes may be candidates for future investigation of gene regulation in breast cancer.

Original language	English
Article number	107241
Journal	Data in Brief
Volume	37
DOIs	https://doi.org/10.1016/j.dib.2021.107241
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
MCDW and JMB are funded by the Dalhousie Medical Research Foundation (DMRF) Genomics in Medicine scholarships, Beatrice Hunter Cancer Research Institute (BHCRI) Cancer Research Training Program (CRTP) awards and Research Nova Scotia (RNS) Scotia Scholars awards. MCDW is also supported by Dalhousie University's Faculty of Medicine graduate scholarship. JMB is also supported by the Terry Fox Research Institute . JV and WF are funded by an operating grant to PM from the Canadian Institutes of Health Research (CIHR, PJT 162313 ). JV is also supported by a DMRF PhD Fellowship for Breast Cancer Research. Fig. 5 was created with BioRender.com. This study was funded by CIHR funding to PM ( PJT 162313 ).

Publisher Copyright:
© 2021

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PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Long non-coding RNA (lncRNA)/microRNA (miRNA)/messenger RNA (mRNA) interactions regulate oncogenesis and tumour suppression in breast cancer. Oncogenic lncRNA/miRNA/mRNA axes may offer novel therapeutic targets; therefore, identifying such axes is a clinically relevant undertaking. To explore miRNAs regulated by oncogenic lncRNAs, we queried the NCBI Gene Expression Omnibus (GEO) database to find datasets that profiled gene expression changes upon lncRNA knockdown in breast cancer. We identified four microarray datasets that permitted our interrogation of genes regulated by lncRNAs LincK, LincIN, SPRY4-IT1 and AC009283.1. We specifically analysed changes in miRNA transcripts within these datasets to study miRNAs regulated by each of the four lncRNAs. We subsequently identified the predicted mRNA targets for these miRNAs to uncover possible lncRNA/miRNA/mRNAs axes in breast cancer. These axes may be candidates for future investigation of gene regulation in breast cancer.",

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Datasets exploring putative lncRNA-miRNA-mRNA axes in breast cancer cell lines

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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