Abstract
The elimination of theophylline is decreased after vaccination against influenza. In 3 patients receiving 200 mg of oxtriphylline (equivalent to 128 mg of theophylline) every 6 hours by mouth the serum theophylline levels rose after vaccination, and in 4 healthy volunteers given the same dose of oxtriphylline 24 hours after vaccination the half-life of theophylline increased by an average of 122%. Two of the 3 patients showed signs of a toxic reaction to the drug. These results suggest that the elimination of theophylline is impaired to a clinically important degree after influenza vaccination and that the resulting levels of the drug can be toxic even when conventional therapeutic doses of theophylline are given.
| Original language | English |
|---|---|
| Pages (from-to) | 288-290 |
| Number of pages | 3 |
| Journal | Canadian Medical Association Journal |
| Volume | 123 |
| Issue number | 4 |
| Publication status | Published - 1980 |
ASJC Scopus Subject Areas
- General Medicine
