Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence

Steven Paul Woods, Julie D. Rippeth, Emily Conover, Assawin Gongvatana, Raul Gonzalez, Catherine L. Carey, Mariana Cherner, Robert K. Heaton, Igor Grant, J. Hampton Atkinson, J. Allen McCutchan, Thomas D. Marcotte, Mark R. Wallace, Ronald J. Ellis, Scott Letendre, Rachel Schrier, Joseph Sadek, Terry Jernigan, John Hesselink, Michael J. TaylorEliezer Masliah, Dianne Langford, Daniel R. Masys, Michelle Frybarger, Ian Abramson, Deborah Lazzaretto

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

Methamphetamine (MA) dependence is associated with deficits in episodic verbal memory, but the cognitive mechanisms underlying such impairments are not known. The authors evaluated a component process model of episodic verbal memory in 87 persons with MA dependence (MA+) and 71 demographically similar non-MA-using controls (MA-). Compared with MA- controls, MA+ participants demonstrated deficient overall learning, free recall, and utilization of semantic clustering, as well as higher rates of repetitions and intrusions. No between-groups differences were evident on measures of serial clustering, retention, or recognition discrimination. Taken together, these findings indicate that MA dependence is associated with deficient strategic (i.e., executive) control of verbal encoding and retrieval, which is consistent with the sequelae of MA-related prefronto-striatal circuit neurotoxicity.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalNeuropsychology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2005
Externally publishedYes

ASJC Scopus Subject Areas

  • Neuropsychology and Physiological Psychology

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Woods, S. P., Rippeth, J. D., Conover, E., Gongvatana, A., Gonzalez, R., Carey, C. L., Cherner, M., Heaton, R. K., Grant, I., Atkinson, J. H., McCutchan, J. A., Marcotte, T. D., Wallace, M. R., Ellis, R. J., Letendre, S., Schrier, R., Sadek, J., Jernigan, T., Hesselink, J., ... Lazzaretto, D. (2005). Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence. Neuropsychology, 19(1), 35-43. https://doi.org/10.1037/0894-4105.19.1.35