Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus

B. R. Christie; A. M. Li; V. A. Redila; H. Booth; B. K.Y. Wong; B. D. Eadie; C. Ernst; E. M. Simpson

doi:10.1016/j.neuroscience.2005.08.091

Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus

B. R. Christie, A. M. Li, V. A. Redila, H. Booth, B. K.Y. Wong, B. D. Eadie, C. Ernst, E. M. Simpson

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The spontaneous or targeted deletion of the nuclear receptor transcription factor Nr2e1 produces a mouse that shows hypoplasia of the hippocampal formation and reduced neurogenesis in adult mice. In these studies we show that hippocampal synaptic transmission appears normal in the dentate gyrus and cornu ammonis 1 subfields of adult mice that lack Nr2e1 (Nr2e1^-/-), and that fEPSP shape, paired-pulse responses, and short-term plasticity are not substantially altered in either subfield. In contrast, the expression of long-term potentiation is selectively impaired in the dentate gyrus, and not in the cornu ammonis 1 subfield. Golgi analysis revealed that there was a significant reduction in both dendritic branching and dendritic length that was specific to dentate gyrus granule cells in the Nr2e1^-/- mice. These results indicate that Nr2e1 deletion can significantly alter both synaptic plasticity and dendritic structure in the dentate gyrus.

Original language	English
Pages (from-to)	1031-1037
Number of pages	7
Journal	Neuroscience
Volume	137
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroscience.2005.08.091
Publication status	Published - 2006
Externally published	Yes

Bibliographical note

Funding Information:
The authors are grateful for support from NSERC, CIHR, the BC Ministry of Children and Development and the Human Early Learning Project (HELP) to B.R.C. We also acknowledge CIHR and a Canada Research Chair in Genetics and Behaviour to E.M.S. B.K.Y.W. and B.D.E. are SRCF of Canada Fellowship recipients. B.K.Y.W. is also a NAAR recipient. C.E. and B.D.E. are NSERC PGS recipients. B.R.C. is the BMO Young Investigator at UBC Hospital.

ASJC Scopus Subject Areas

General Neuroscience

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10.1016/j.neuroscience.2005.08.091

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title = "Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus",

abstract = "The spontaneous or targeted deletion of the nuclear receptor transcription factor Nr2e1 produces a mouse that shows hypoplasia of the hippocampal formation and reduced neurogenesis in adult mice. In these studies we show that hippocampal synaptic transmission appears normal in the dentate gyrus and cornu ammonis 1 subfields of adult mice that lack Nr2e1 (Nr2e1-/-), and that fEPSP shape, paired-pulse responses, and short-term plasticity are not substantially altered in either subfield. In contrast, the expression of long-term potentiation is selectively impaired in the dentate gyrus, and not in the cornu ammonis 1 subfield. Golgi analysis revealed that there was a significant reduction in both dendritic branching and dendritic length that was specific to dentate gyrus granule cells in the Nr2e1-/- mice. These results indicate that Nr2e1 deletion can significantly alter both synaptic plasticity and dendritic structure in the dentate gyrus.",

author = "Christie, {B. R.} and Li, {A. M.} and Redila, {V. A.} and H. Booth and Wong, {B. K.Y.} and Eadie, {B. D.} and C. Ernst and Simpson, {E. M.}",

note = "Funding Information: The authors are grateful for support from NSERC, CIHR, the BC Ministry of Children and Development and the Human Early Learning Project (HELP) to B.R.C. We also acknowledge CIHR and a Canada Research Chair in Genetics and Behaviour to E.M.S. B.K.Y.W. and B.D.E. are SRCF of Canada Fellowship recipients. B.K.Y.W. is also a NAAR recipient. C.E. and B.D.E. are NSERC PGS recipients. B.R.C. is the BMO Young Investigator at UBC Hospital.",

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AU - Booth, H.

AU - Wong, B. K.Y.

AU - Eadie, B. D.

AU - Ernst, C.

AU - Simpson, E. M.

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PY - 2006

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N2 - The spontaneous or targeted deletion of the nuclear receptor transcription factor Nr2e1 produces a mouse that shows hypoplasia of the hippocampal formation and reduced neurogenesis in adult mice. In these studies we show that hippocampal synaptic transmission appears normal in the dentate gyrus and cornu ammonis 1 subfields of adult mice that lack Nr2e1 (Nr2e1-/-), and that fEPSP shape, paired-pulse responses, and short-term plasticity are not substantially altered in either subfield. In contrast, the expression of long-term potentiation is selectively impaired in the dentate gyrus, and not in the cornu ammonis 1 subfield. Golgi analysis revealed that there was a significant reduction in both dendritic branching and dendritic length that was specific to dentate gyrus granule cells in the Nr2e1-/- mice. These results indicate that Nr2e1 deletion can significantly alter both synaptic plasticity and dendritic structure in the dentate gyrus.

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Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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