Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder

GAGE-BD initiative

doi:10.1111/acps.13474

Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder

GAGE-BD initiative

Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Objectives: There is limited information on the characteristics of older adults with bipolar disorder (OABD) treated with lithium, along with safety concerns about its use by older adults. The aim of the present study is to describe the demographic and clinical characteristics of OABD receiving lithium therapy, using data from the Global Ageing & Geriatric Experiments in Bipolar Disorder (GAGE-BD). Experimental Procedures: Cross-sectional analysis of the GAGE-BD dataset to determine differences and similarities between lithium users and non-users. We analysed data from 986 participants aged 50 years or older (mean age 63.5 years; 57.5% females) from 12 study sites. Two subgroups (‘Lithium’; ‘Non-lithium’) were defined according to the current prescription of lithium. We compared several outcomes between these groups, controlling for age, gender, and study site. Results: OABD treated with lithium had lower scores on depression rating scales and were less likely to be categorised as with moderate or severe depression. There was a lower proportion of lithium users than non-users among those with evidence of rapid cycling and non-bipolar psychiatric diagnoses. Assessment of global cognitive state and functionality indicated better performance among lithium users. The current use of antipsychotics was less frequent among lithium users, who also reported fewer cardiovascular comorbidities than non-users. Conclusion: We found several potentially relevant differences in the clinical profile of OABD treated with lithium compared with those treated with other mood stabilisers. However, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonisation.

Original language	English
Journal	Acta Psychiatrica Scandinavica
DOIs	https://doi.org/10.1111/acps.13474
Publication status	Accepted/In press - 2022

Bibliographical note

Funding Information:
Research reported in this publication was supported by the ISBD Bowden Massey Strategic Research Initiative in Bipolar Disorder Award and made possible by logistical support from the ISBD. Support was also received from the Clinical and Translational Science Collaborative (CTSC) of Cleveland which is funded by the National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548). Hilary Blumberg is supported by (NIH grant R01 MH113230). The corresponding author's work is supported by research grants from FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465,412/2014‐9) and Associação Beneficente Alzira Denise Hertzog da Silva (ABADHS).

Funding Information:
Bowden Massey Strategic Research Initiative in Bipolar Disorder Award; Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University; FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465412/2014‐9); National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548); NIH grant R01 MH113230 Funding information

Publisher Copyright:
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ASJC Scopus Subject Areas

Psychiatry and Mental health

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/acps.13474

Cite this

@article{2f8501fd149b41eaaef66f9642fb3fbf,

title = "Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder",

abstract = "Objectives: There is limited information on the characteristics of older adults with bipolar disorder (OABD) treated with lithium, along with safety concerns about its use by older adults. The aim of the present study is to describe the demographic and clinical characteristics of OABD receiving lithium therapy, using data from the Global Ageing & Geriatric Experiments in Bipolar Disorder (GAGE-BD). Experimental Procedures: Cross-sectional analysis of the GAGE-BD dataset to determine differences and similarities between lithium users and non-users. We analysed data from 986 participants aged 50 years or older (mean age 63.5 years; 57.5% females) from 12 study sites. Two subgroups ({\textquoteleft}Lithium{\textquoteright}; {\textquoteleft}Non-lithium{\textquoteright}) were defined according to the current prescription of lithium. We compared several outcomes between these groups, controlling for age, gender, and study site. Results: OABD treated with lithium had lower scores on depression rating scales and were less likely to be categorised as with moderate or severe depression. There was a lower proportion of lithium users than non-users among those with evidence of rapid cycling and non-bipolar psychiatric diagnoses. Assessment of global cognitive state and functionality indicated better performance among lithium users. The current use of antipsychotics was less frequent among lithium users, who also reported fewer cardiovascular comorbidities than non-users. Conclusion: We found several potentially relevant differences in the clinical profile of OABD treated with lithium compared with those treated with other mood stabilisers. However, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonisation.",

author = "{GAGE-BD initiative} and Forlenza, {Orestes V.} and Tomas Hajek and Almeida, {Osvaldo P.} and Beunders, {Alexandra J.M.} and Blumberg, {Hilary P.} and Briggs, {Farren B.S.} and De-Paula, {Vanessa J.R.} and Annemiek Dols and Eyler, {Lisa T.} and Forester, {Brent P.} and Ariel Gildengers and Esther Jimenez and Korten, {Nicole C.M.} and Beny Lafer and McWhinney, {Sean R.} and Benoit Mulsant and Soham Rej and Kaylee Sarna and Sigfried Schouws and Ashley Sutherland and Shangying Tsai and Eduard Vieta and Joy Yala and Martha Sajatovic",

note = "Funding Information: Research reported in this publication was supported by the ISBD Bowden Massey Strategic Research Initiative in Bipolar Disorder Award and made possible by logistical support from the ISBD. Support was also received from the Clinical and Translational Science Collaborative (CTSC) of Cleveland which is funded by the National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548). Hilary Blumberg is supported by (NIH grant R01 MH113230). The corresponding author's work is supported by research grants from FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465,412/2014‐9) and Associa{\c c}{\~a}o Beneficente Alzira Denise Hertzog da Silva (ABADHS). Funding Information: Bowden Massey Strategic Research Initiative in Bipolar Disorder Award; Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University; FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465412/2014‐9); National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548); NIH grant R01 MH113230 Funding information Publisher Copyright: {\textcopyright} 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2022",

doi = "10.1111/acps.13474",

language = "English",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder

AU - GAGE-BD initiative

AU - Forlenza, Orestes V.

AU - Hajek, Tomas

AU - Almeida, Osvaldo P.

AU - Beunders, Alexandra J.M.

AU - Blumberg, Hilary P.

AU - Briggs, Farren B.S.

AU - De-Paula, Vanessa J.R.

AU - Dols, Annemiek

AU - Eyler, Lisa T.

AU - Forester, Brent P.

AU - Gildengers, Ariel

AU - Jimenez, Esther

AU - Korten, Nicole C.M.

AU - Lafer, Beny

AU - McWhinney, Sean R.

AU - Mulsant, Benoit

AU - Rej, Soham

AU - Sarna, Kaylee

AU - Schouws, Sigfried

AU - Sutherland, Ashley

AU - Tsai, Shangying

AU - Vieta, Eduard

AU - Yala, Joy

AU - Sajatovic, Martha

N1 - Funding Information: Research reported in this publication was supported by the ISBD Bowden Massey Strategic Research Initiative in Bipolar Disorder Award and made possible by logistical support from the ISBD. Support was also received from the Clinical and Translational Science Collaborative (CTSC) of Cleveland which is funded by the National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548). Hilary Blumberg is supported by (NIH grant R01 MH113230). The corresponding author's work is supported by research grants from FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465,412/2014‐9) and Associação Beneficente Alzira Denise Hertzog da Silva (ABADHS). Funding Information: Bowden Massey Strategic Research Initiative in Bipolar Disorder Award; Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University; FAPESP (2019/08507‐3, 2014/50873‐3), CNPq (465412/2014‐9); National Institutes of Health (NIH), National Center for Advancing Translational Science (NCATS), Clinical and Translational Science Award (CTSA) grant (UL1TR002548); NIH grant R01 MH113230 Funding information Publisher Copyright: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2022

Y1 - 2022

N2 - Objectives: There is limited information on the characteristics of older adults with bipolar disorder (OABD) treated with lithium, along with safety concerns about its use by older adults. The aim of the present study is to describe the demographic and clinical characteristics of OABD receiving lithium therapy, using data from the Global Ageing & Geriatric Experiments in Bipolar Disorder (GAGE-BD). Experimental Procedures: Cross-sectional analysis of the GAGE-BD dataset to determine differences and similarities between lithium users and non-users. We analysed data from 986 participants aged 50 years or older (mean age 63.5 years; 57.5% females) from 12 study sites. Two subgroups (‘Lithium’; ‘Non-lithium’) were defined according to the current prescription of lithium. We compared several outcomes between these groups, controlling for age, gender, and study site. Results: OABD treated with lithium had lower scores on depression rating scales and were less likely to be categorised as with moderate or severe depression. There was a lower proportion of lithium users than non-users among those with evidence of rapid cycling and non-bipolar psychiatric diagnoses. Assessment of global cognitive state and functionality indicated better performance among lithium users. The current use of antipsychotics was less frequent among lithium users, who also reported fewer cardiovascular comorbidities than non-users. Conclusion: We found several potentially relevant differences in the clinical profile of OABD treated with lithium compared with those treated with other mood stabilisers. However, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonisation.

AB - Objectives: There is limited information on the characteristics of older adults with bipolar disorder (OABD) treated with lithium, along with safety concerns about its use by older adults. The aim of the present study is to describe the demographic and clinical characteristics of OABD receiving lithium therapy, using data from the Global Ageing & Geriatric Experiments in Bipolar Disorder (GAGE-BD). Experimental Procedures: Cross-sectional analysis of the GAGE-BD dataset to determine differences and similarities between lithium users and non-users. We analysed data from 986 participants aged 50 years or older (mean age 63.5 years; 57.5% females) from 12 study sites. Two subgroups (‘Lithium’; ‘Non-lithium’) were defined according to the current prescription of lithium. We compared several outcomes between these groups, controlling for age, gender, and study site. Results: OABD treated with lithium had lower scores on depression rating scales and were less likely to be categorised as with moderate or severe depression. There was a lower proportion of lithium users than non-users among those with evidence of rapid cycling and non-bipolar psychiatric diagnoses. Assessment of global cognitive state and functionality indicated better performance among lithium users. The current use of antipsychotics was less frequent among lithium users, who also reported fewer cardiovascular comorbidities than non-users. Conclusion: We found several potentially relevant differences in the clinical profile of OABD treated with lithium compared with those treated with other mood stabilisers. However, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonisation.

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Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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