Differences in baseline joint moments and muscle activation patterns associated with knee osteoarthritis progression when defined using a clinical versus a structural outcome

Kerry E. Costello; Janie L. Astephen Wilson; William D. Stanish; Nathan Urquhart; Cheryl L. Hubley-Kozey

doi:10.1123/JAB.2019-0127

Differences in baseline joint moments and muscle activation patterns associated with knee osteoarthritis progression when defined using a clinical versus a structural outcome

Kerry E. Costello, Janie L. Astephen Wilson, William D. Stanish, Nathan Urquhart, Cheryl L. Hubley-Kozey

Medicine

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Both structural and clinical changes can signify knee osteoarthritis progression; however, these changes are not always concurrent. A better understanding of mechanical factors associated with progression and whether they differ for structural versus clinical outcomes could lead to improved conservative management. This study examined baseline gait differences between progression and no progression groups defined at an average of 7-year follow-up using 2 different outcomes indicative of knee osteoarthritis progression: radiographic medial joint space narrowing and total knee arthroplasty. Of 49 individuals with knee osteoarthritis who underwent baseline gait analysis, 32 progressed and 17 did not progress using the radiographic outcome, while 13 progressed and 36 did not progress using the arthroplasty outcome. Key knee moment and electromyography waveform features were extracted using principal component analysis, and confidence intervals were used to examine between-group differences in these metrics. Those who progressed using the arthroplasty outcome had prolonged rectus femoris and lateral hamstrings muscle activation compared with the no arthroplasty group. Those with radiographic progression had greater mid-stance internal knee rotation moments compared with the no radiographic progression group. These results provide preliminary evidence for the role of prolonged muscle activation in total knee arthroplasty, while radiographic changes may be related to loading magnitude.

Original language	English
Pages (from-to)	39-51
Number of pages	13
Journal	Journal of Applied Biomechanics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1123/JAB.2019-0127
Publication status	Published - Feb 2020

Bibliographical note

Funding Information:
The authors wish to thank the study participants and acknowledge the staff and students of the Dynamics of Human Motion Laboratory for assistance with participant recruitment and data collection. The authors are also indebted to Drs Michael LaValley and Deepak Kumar for thoughtful discussions pertaining to the statistical approaches utilized in this study. This research was supported by funding from the Canadian Institutes for Health Research (reference number: 142713), the Nova Scotia Health Research Foundation (Scotia Scholar [K.E.C.] and Scotia Support Grant [Sponsorship ID number: MED 0SSG-2011-7591]), and a Killam Predoctoral Scholarship (K.E.C.). The authors have no conflicts of interest to disclose.

Publisher Copyright:
© 2020 Human Kinetics, Inc.

ASJC Scopus Subject Areas

Biophysics
Orthopedics and Sports Medicine
Rehabilitation

PubMed: MeSH publication types

Journal Article

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10.1123/JAB.2019-0127

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Differences in baseline joint moments and muscle activation patterns associated with knee osteoarthritis progression when defined using a clinical versus a structural outcome. / Costello, Kerry E.; Astephen Wilson, Janie L.; Stanish, William D. et al.
In: Journal of Applied Biomechanics, Vol. 36, No. 1, 02.2020, p. 39-51.

Research output: Contribution to journal › Article › peer-review

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Differences in baseline joint moments and muscle activation patterns associated with knee osteoarthritis progression when defined using a clinical versus a structural outcome

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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